TCL6 explained

In molecular biology, T-cell leukemia/lymphoma 6 (non-protein coding), also known as TCL6 is a long non-coding RNA. It is expressed in T-cell leukemia with a t(14;14)(q11;q32.1) chromosome translocation in humans and in a mouse model. It is not expressed in normal T-cells.^{[1] [2]} It may be involved in leukemogenesis.

See also

• Long noncoding RNA

Notes and References

1. Hallas C, Pekarsky Y, Itoyama T, Varnum J, Bichi R, Rothstein JL, etal . Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes. . Proc Natl Acad Sci U S A . 1999 . 96 . 25 . 14418–14423 . 10588720 . 10.1073/pnas.96.25.14418. 24451 . 1999PNAS...9614418H . free .
2. Saitou M, Sugimoto J, Hatakeyama T, Russo G, Isobe M . Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. . Oncogene . 2000 . 19 . 23 . 2796–2802 . 10851082 . 10.1038/sj.onc.1203604 . free .