TCL1 MTCP1 protein domain explained

Symbol:	TCL1_MTCP1
TCL1_MTCP1
Pfam:	PF01840
Interpro:	IPR004832
Scop:	1jsg

In molecular biology, TCL-1/MTCP-1 is a protein domain found in proteins encoded for by two related protooncogenes, other words by genes that help promote cancer. They are, T-cell leukemia/lymphoma protein 1A TCL1A encoded by oncogene TCL-1 SWISSPROT and Protein p13 MTCP-1 encoded by MTCP-1 SWISSPROT.

These are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28.^[1]

Function

Enhances the phosphorylation and activation of Akt. Once Akt is activated this will in turn trigger cell survival. Further more it helps to stabilise mitochondrial membrane potential.^{[2] [3]}

Structure

This protein exists as a homodimer. It interacts with AKT1, AKT2 and AKT3 via the PH protein domain. It interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.

Notes and References

1. Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW . Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies . Proc. Natl. Acad. Sci. U.S.A. . 95 . 7 . 3413–8 . March 1998 . 9520380 . 19850 . 10.1073/pnas.95.7.3413. 1998PNAS...95.3413F . free .
2. Pekarsky Y, Koval A, Hallas C, Bichi R, Tresini M, Malstrom S, etal . Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. . Proc Natl Acad Sci U S A . 2000 . 97 . 7 . 3028–33 . 10716693 . 10.1073/pnas.040557697 . 16186 . free .
3. Laine J, Künstle G, Obata T, Sha M, Noguchi M . The protooncogene TCL1 is an Akt kinase coactivator. . Mol Cell . 2000 . 6 . 2 . 395–407 . 10983986 . 10.1016/S1097-2765(00)00039-3. free .