TCL1A explained

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.^{[1] [2] [3]}

Interactions

TCL1A has been shown to interact with AKT1^{[4] [5] [6]} and AKT2.^{[4] [5]}

Further reading

• Pekarsky Y, Hallas C, Croce CM . The role of TCL1 in human T-cell leukemia . Oncogene . 20 . 40 . 5638–43 . 2001 . 11607815 . 10.1038/sj.onc.1204596 . free .
• Pekarsky Y, Zanesi N, Aqeilan R, Croce CM . Tcl1 as a model for lymphomagenesis . Hematol. Oncol. Clin. North Am. . 18 . 4 . 863–79, ix . 2004 . 15325703 . 10.1016/j.hoc.2004.04.007 .
• Noguchi M, Ropars V, Roumestand C, Suizu F . Proto-oncogene TCL1: more than just a coactivator for Akt . FASEB J. . 21 . 10 . 2273–84 . 2007 . 17360849 . 10.1096/fj.06-7684com . free . 16946256 .
• Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM . Characterization and localization of the TCL-1 oncogene product . Cancer Res. . 54 . 24 . 6297–301 . 1995 . 7987816 .
• Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H . Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology . Structure . 6 . 2 . 147–55 . 1998 . 9519406 . 10.1016/S0969-2126(98)00017-3 . free .
• Takizawa J, Suzuki R, Kuroda H, Utsunomiya A, Kagami Y, Joh T, Aizawa Y, Ueda R, Seto M . Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia . Jpn. J. Cancer Res. . 89 . 7 . 712–8 . 1998 . 9738977 . 5921886 . 10.1111/j.1349-7006.1998.tb03275.x .
• Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM . Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes . Proc. Natl. Acad. Sci. U.S.A. . 96 . 6 . 2949–51 . 1999 . 10077617 . 15875 . 10.1073/pnas.96.6.2949 . 1999PNAS...96.2949P . free .
• Laine J, Künstle G, Obata T, Sha M, Noguchi M . The protooncogene TCL1 is an Akt kinase coactivator . Mol. Cell . 6 . 2 . 395–407 . 2000 . 10983986 . 10.1016/S1097-2765(00)00039-3 . free .
• Laine J, Künstle G, Obata T, Noguchi M . Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family . J. Biol. Chem. . 277 . 5 . 3743–51 . 2002 . 11707444 . 10.1074/jbc.M107069200 . free .
• French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA . A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane . Biochemistry . 41 . 20 . 6376–82 . 2002 . 12009899 . 10.1021/bi016068o .
• Fears S, Chakrabarti SR, Nucifora G, Rowley JD . Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression . Cancer Genet. Cytogenet. . 135 . 2 . 110–9 . 2002 . 12127395 . 10.1016/S0165-4608(01)00655-0 .
• Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC, Teitell MA . Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma . Proc. Natl. Acad. Sci. U.S.A. . 99 . 22 . 14392–7 . 2002 . 12381789 . 137894 . 10.1073/pnas.212410199 . 2002PNAS...9914392H . free .
• French SW, Malone CS, Shen RR, Renard M, Henson SE, Miner MD, Wall R, Teitell MA . Sp1 transactivation of the TCL1 oncogene . J. Biol. Chem. . 278 . 2 . 948–55 . 2003 . 12421830 . 10.1074/jbc.M207166200 . free .
• Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D . TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin . Blood . 101 . 12 . 5007–9 . 2004 . 12576313 . 10.1182/blood-2002-10-3297 . 17149852 .
• Kiss C, Nishikawa J, Takada K, Trivedi P, Klein G, Szekely L . T cell leukemia I oncogene expression depends on the presence of Epstein–Barr virus in the virus- carrying Burkitt lymphoma lines . Proc. Natl. Acad. Sci. U.S.A. . 100 . 8 . 4813–8 . 2003 . 12672960 . 153638 . 10.1073/pnas.0730710100 . 2003PNAS..100.4813K . free .

Notes and References

1. Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM . Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient . Proc Natl Acad Sci U S A . 86 . 2 . 602–6 . February 1989 . 2783489 . 286520 . 10.1073/pnas.86.2.602 . 1989PNAS...86..602R . free .
2. Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G . Identification of the TCL1 gene involved in T-cell malignancies . Proc Natl Acad Sci U S A . 91 . 26 . 12530–4 . February 1995 . 7809072 . 45472 . 10.1073/pnas.91.26.12530 . free .
3. Web site: Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A.
4. Laine J, Künstle G, Obata T, Noguchi M . Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family . J. Biol. Chem. . 277 . 5 . 3743–51 . February 2002 . 11707444 . 10.1074/jbc.M107069200 . free .
5. Laine J, Künstle G, Obata T, Sha M, Noguchi M . The protooncogene TCL1 is an Akt kinase coactivator . Mol. Cell . 6 . 2 . 395–407 . August 2000 . 10983986 . 10.1016/S1097-2765(00)00039-3 . free .
6. French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA . A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane . Biochemistry . 41 . 20 . 6376–82 . May 2002 . 12009899 . 10.1021/bi016068o .