TCIM explained

TCIM is a protein that in humans is encoded by the TCIM gene.^{[1] [2]}

Function

This gene encodes a small, monomeric, predominantly unstructured protein (106 amino acids, 12.3 kDa, isoelectric point 9.39).^[3] It is a positive regulator of the Wnt / beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes.^[2]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Sunde M, McGrath KC, Young L, Matthews JM, Chua EL, Mackay JP, Death AK . TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer . Cancer Research . 64 . 8 . 2766–73 . April 2004 . 15087392 . 10.1158/0008-5472.CAN-03-2093 .
• Friedman JB, Brunschwig EB, Platzer P, Wilson K, Markowitz SD . C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer . International Journal of Cancer . 111 . 1 . 72–5 . August 2004 . 15185345 . 10.1002/ijc.20235 . 19983783 .
• Jung Y, Bang S, Choi K, Kim E, Kim Y, Kim J, Park J, Koo H, Moon RT, Song K, Lee I . TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby . Cancer Research . 66 . 2 . 723–8 . January 2006 . 16424001 . 10.1158/0008-5472.CAN-05-3124 . free .
• Kim B, Koo H, Yang S, Bang S, Jung Y, Kim Y, Kim J, Park J, Moon RT, Song K, Lee I . TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer . Clinical Cancer Research . 12 . 11 Pt 1 . 3541–8 . June 2006 . 16740781 . 10.1158/1078-0432.CCR-05-2440 . free .
• Yang ZQ, Streicher KL, Ray ME, Abrams J, Ethier SP . Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer . Cancer Research . 66 . 24 . 11632–43 . December 2006 . 17178857 . 10.1158/0008-5472.CAN-06-2946 . free .
• Yang ZQ, Moffa AB, Haddad R, Streicher KL, Ethier SP . Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways . International Journal of Cancer . 121 . 6 . 1265–73 . September 2007 . 17520678 . 10.1002/ijc.22831 . 25292320 . free .
• Park J, Jung Y, Kim J, Kim KY, Ahn SG, Song K, Lee I . TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response . Biochemical and Biophysical Research Communications . 360 . 2 . 447–52 . August 2007 . 17603013 . 10.1016/j.bbrc.2007.06.077 .

Notes and References

1. Chua EL, Young L, Wu WM, Turtle JR, Dong Q . Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer . Genomics . 69 . 3 . 342–7 . November 2000 . 11056052 . 10.1006/geno.2000.6348 .
2. Web site: Entrez Gene: C8orf4 chromosome 8 open reading frame 4.
3. Kozlowski LP . IPC - Isoelectric Point Calculator . Biology Direct . 11 . 1 . 55 . October 2016 . 27769290 . 10.1186/s13062-016-0159-9 . 5075173 . free .