TCF7 explained

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.^[1]

Further reading

• van de Wetering M, Oosterwegel M, Holstege F, etal . The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. . J. Biol. Chem. . 267 . 12 . 8530–6 . 1992 . 10.1016/S0021-9258(18)42476-3 . 1569101 . free .
• van de Wetering M, Oosterwegel M, Dooijes D, Clevers H . Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. . EMBO J. . 10 . 1 . 123–32 . 1991 . 1989880 . 10.1002/j.1460-2075.1991.tb07928.x. 452620 .
• Castrop J, van Wichen D, Koomans-Bitter M, etal . The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes. . Blood . 86 . 8 . 3050–9 . 1995 . 7579399 . 10.1182/blood.V86.8.3050.3050. free . 20.500.11755/05a0e0d7-f80c-4035-a8da-056c8b5b7883 . free .
• Mayer K, Wolff E, Clevers H, Ballhausen WG . The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA. . Biochim. Biophys. Acta . 1263 . 2 . 169–72 . 1995 . 7640309 . 10.1016/0167-4781(95)00108-s.
• Van de Wetering M, Castrop J, Korinek V, Clevers H . Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. . Mol. Cell. Biol. . 16 . 3 . 745–52 . 1996 . 8622675 . 10.1128/mcb.16.3.745. 231054 .
• Korinek V, Barker N, Willert K, etal . Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. . Mol. Cell. Biol. . 18 . 3 . 1248–56 . 1998 . 9488439 . 10.1128/MCB.18.3.1248. 108837 .
• Roose J, Molenaar M, Peterson J, etal . The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. . Nature . 395 . 6702 . 608–12 . 1998 . 9783587 . 10.1038/26989 . 1998Natur.395..608R . 4347003 .
• Roose J, Huls G, van Beest M, etal . Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. . Science . 285 . 5435 . 1923–6 . 1999 . 10489374 . 10.1126/science.285.5435.1923 .
• Brantjes H, Roose J, van De Wetering M, Clevers H . All Tcf HMG box transcription factors interact with Groucho-related co-repressors. . Nucleic Acids Res. . 29 . 7 . 1410–9 . 2001 . 11266540 . 10.1093/nar/29.7.1410 . 31284 .
• Batlle E, Henderson JT, Beghtel H, etal . Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. . Cell . 111 . 2 . 251–63 . 2002 . 12408869 . 10.1016/S0092-8674(02)01015-2 . 10103038 . free .
• Noble JA, White AM, Lazzeroni LC, etal . A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. . Diabetes . 52 . 6 . 1579–82 . 2003 . 12765974 . 10.2337/diabetes.52.6.1579 . free .
• Ioannidis V, Kunz B, Tanamachi DM, etal . Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1. . J. Immunol. . 171 . 2 . 769–75 . 2003 . 12847244 . 10.4049/jimmunol.171.2.769. free .
• Smit L, Baas A, Kuipers J, etal . Wnt activates the Tak1/Nemo-like kinase pathway. . J. Biol. Chem. . 279 . 17 . 17232–40 . 2004 . 14960582 . 10.1074/jbc.M307801200 . free .
• Smith SS, Patterson T, Pauza ME . Transgenic Ly-49A inhibits antigen-driven T cell activation and delays diabetes. . J. Immunol. . 174 . 7 . 3897–905 . 2005 . 15778344 . 10.4049/jimmunol.174.7.3897. free .
• Willinger T, Freeman T, Herbert M, etal . Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. . J. Immunol. . 176 . 3 . 1439–46 . 2006 . 16424171 . 10.4049/jimmunol.176.3.1439. free . 20.500.11820/b4e3a221-e38b-4f3a-9dbe-1641533de25a . free .

Notes and References

1. Web site: Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box).