TCF20 explained

Transcription factor 20 is a protein that in humans is encoded by the TCF20 gene.^{[1] [2] [3]}

The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms.

Interactions

TCF20 has been shown to interact with RNF4.^[4]

Further reading

• Sanz L, Moscat J, Diaz-Meco MT . Molecular characterization of a novel transcription factor that controls stromelysin expression . Molecular and Cellular Biology . 15 . 6 . 3164–70 . June 1995 . 7760812 . 230548 . 10.1128/mcb.15.6.3164 .
• Kirstein M, Sanz L, Quiñones S, Moscat J, Diaz-Meco MT, Saus J . Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene . The Journal of Biological Chemistry . 271 . 30 . 18231–6 . July 1996 . 8663478 . 10.1074/jbc.271.30.18231 . free .
• Ohara O, Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Nomura N . Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins . DNA Research . 4 . 1 . 53–9 . February 1997 . 9179496 . 10.1093/dnares/4.1.53 . 10.1.1.325.2199 .
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . December 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P . Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers . The Journal of Biological Chemistry . 275 . 34 . 26144–9 . August 2000 . 10849425 . 10.1074/jbc.M003405200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nature Biotechnology . 23 . 1 . 94–101 . January 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Gburcik V, Bot N, Maggiolini M, Picard D . SPBP is a phosphoserine-specific repressor of estrogen receptor alpha . Molecular and Cellular Biology . 25 . 9 . 3421–30 . May 2005 . 15831449 . 1084313 . 10.1128/MCB.25.9.3421-3430.2005 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
• Sjøttem E, Rekdal C, Svineng G, Johnsen SS, Klenow H, Uglehus RD, Johansen T . The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription . Nucleic Acids Research . 35 . 19 . 6648–62 . 2007 . 17913746 . 2095823 . 10.1093/nar/gkm739 .

Notes and References

1. Rajadhyaksha A, Rivière M, Van Vooren P, Szpirer J, Szpirer C, Babin J, Bina M . Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization . Cytogenetics and Cell Genetics . 81 . 3–4 . 176–7 . October 1998 . 9730594 . 10.1159/000015021 . 46832690 .
2. Rekdal C, Sjøttem E, Johansen T . The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators . The Journal of Biological Chemistry . 275 . 51 . 40288–300 . December 2000 . 10995766 . 10.1074/jbc.M006978200 . free .
3. Web site: Entrez Gene: TCF20 transcription factor 20 (AR1).
4. Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P . Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers . The Journal of Biological Chemistry . 275 . 34 . 26144–9 . August 2000 . 10849425 . 10.1074/jbc.M003405200 . free .