TCEAL1 explained

Transcription elongation factor A protein-like 1 is a protein that in humans is encoded by the TCEAL1 gene.^{[1] [2]}

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.^[3]

Further reading

• Yeh CH, Zong WX, Shatkin AJ . The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression . J. Biol. Chem. . 270 . 43 . 25313–5 . 1995 . 7592688 . 10.1074/jbc.270.44.26558 . free .
• Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ . Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR . Genomics . 56 . 2 . 217–20 . 1999 . 10051408 . 10.1006/geno.1998.5705 .
• van der Kuip H, Carius B, Haque SJ, etal . The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins . J. Mol. Med. . 77 . 4 . 386–92 . 1999 . 10353443 . 10.1007/s001090050365 . 22183443 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ross MT, Grafham DV, Coffey AJ, etal . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R .
• Makino H, Tajiri T, Miyashita M, etal . Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis . Diseases of the Esophagus . 18 . 1 . 37–40 . 2005 . 15773840 . 10.1111/j.1442-2050.2005.00432.x . free .
• Oh JH, Yang JO, Hahn Y, etal . Transcriptome analysis of human gastric cancer . Mamm. Genome . 16 . 12 . 942–54 . 2006 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Yeh CH, Shatkin AJ . A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII . Gene . 143 . 2 . 285–7 . Jul 1994 . 8206389 . 10.1016/0378-1119(94)90112-0 .
2. Yeh CH, Shatkin AJ . Down-regulation of Rous sarcoma virus long terminal repeat promoter activity by a HeLa cell basic protein . Proc Natl Acad Sci U S A . 91 . 23 . 11002–6 . Dec 1994 . 7971997 . 45154 . 10.1073/pnas.91.23.11002 . 1994PNAS...9111002Y . free .
3. Web site: Entrez Gene: TCEAL1 transcription elongation factor A (SII)-like 1.