TCEA1 explained

Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.^{[1] [2] [3]}

In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic transcription preinitiation complex.^[4] A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.^[5]

Interactions

TCEA1 has been shown to interact with GTF2H1^{[6] [7]} and POLR2A.^{[6] [7] [8]}

Further reading

• Chen HC, England L, Kane CM . Characterization of a HeLa cDNA clone encoding the human SII protein, an elongation factor for RNA polymerase II . Gene . 116 . 2 . 253–8 . July 1992 . 1378807 . 10.1016/0378-1119(92)90522-Q .
• Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG . HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors . Genes & Development . 6 . 4 . 655–66 . April 1992 . 1559613 . 10.1101/gad.6.4.655 . free .
• Yoo OJ, Yoon HS, Baek KH, Jeon CJ, Miyamoto K, Ueno A, Agarwal K . Cloning, expression and characterization of the human transcription elongation factor, TFIIS . Nucleic Acids Research . 19 . 5 . 1073–9 . March 1991 . 1708494 . 333783 . 10.1093/nar/19.5.1073 .
• Reines D, Chamberlin MJ, Kane CM . Transcription elongation factor SII (TFIIS) enables RNA polymerase II to elongate through a block to transcription in a human gene in vitro . The Journal of Biological Chemistry . 264 . 18 . 10799–809 . June 1989 . 10.1016/S0021-9258(18)81692-1 . 2471707 . free .
• Qian X, Jeon C, Yoon H, Agarwal K, Weiss MA . Structure of a new nucleic-acid-binding motif in eukaryotic transcriptional elongation factor TFIIS . Nature . 365 . 6443 . 277–9 . September 1993 . 7626141 . 10.1038/365277a0 . 1993Natur.365..277Q . 10356/94482 . 4367997 . free .
• Yeh CH, Shatkin AJ . A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII . Gene . 143 . 2 . 285–7 . June 1994 . 8206389 . 10.1016/0378-1119(94)90112-0 .
• Umehara T, Kida S, Yamamoto T, Horikoshi M . Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II . Gene . 167 . 1–2 . 297–302 . December 1995 . 8566795 . 10.1016/0378-1119(95)00634-6 .
• Powell W, Bartholomew B, Reines D . Elongation factor SII contacts the 3'-end of RNA in the RNA polymerase II elongation complex . The Journal of Biological Chemistry . 271 . 37 . 22301–4 . September 1996 . 8798387 . 3371613 . 10.1074/jbc.271.37.22301 . free .
• Pan G, Aso T, Greenblatt J . Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators . The Journal of Biological Chemistry . 272 . 39 . 24563–71 . September 1997 . 9305922 . 10.1074/jbc.272.39.24563 . free .
• Li XY, Green MR . The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor . Genes & Development . 12 . 19 . 2992–6 . October 1998 . 9765201 . 317190 . 10.1101/gad.12.19.2992 .
• Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J . 6 . FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO . The Journal of Biological Chemistry . 273 . 42 . 27593–601 . October 1998 . 9765293 . 10.1074/jbc.273.42.27593 . free .
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y . 6 . Protein-protein interaction panel using mouse full-length cDNAs . Genome Research . 11 . 10 . 1758–65 . October 2001 . 11591653 . 311163 . 10.1101/gr.180101 .
• Saso K, Ito T, Natori S, Sekimizu K . Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II . Journal of Biochemistry . 133 . 4 . 493–500 . April 2003 . 12761297 . 10.1093/jb/mvg065 .
• Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A . 6 . Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis . Experimental Cell Research . 288 . 1 . 35–50 . August 2003 . 12878157 . 10.1016/S0014-4827(03)00130-7 .
• Kettenberger H, Armache KJ, Cramer P . Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage . Cell . 114 . 3 . 347–57 . August 2003 . 12914699 . 10.1016/S0092-8674(03)00598-1 . 11858/00-001M-0000-0015-8647-8 . 17184533 . free .
• Tamura K, Miyata K, Sugahara K, Onishi S, Shuin T, Aso T . Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain . Biochemical and Biophysical Research Communications . 309 . 1 . 189–95 . September 2003 . 12943681 . 10.1016/S0006-291X(03)01556-0 .
• Zhang C, Yan H, Burton ZF . Combinatorial control of human RNA polymerase II (RNAP II) pausing and transcript cleavage by transcription factor IIF, hepatitis delta antigen, and stimulatory factor II . The Journal of Biological Chemistry . 278 . 50 . 50101–11 . December 2003 . 14506279 . 10.1074/jbc.M307590200 . free .

Notes and References

1. DiMarco SP, Glover TW, Miller DE, Reines D, Warren ST . Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3 . Genomics . 36 . 1 . 185–8 . August 1996 . 8812434 . 10.1006/geno.1996.0443 .
2. Park H, Baek K, Jeon C, Agarwal K, Yoo O . Characterization of the gene encoding the human transcriptional elongation factor TFIIS . Gene . 139 . 2 . 263–7 . February 1994 . 8112616 . 10.1016/0378-1119(94)90767-6 .
3. Web site: Entrez Gene: TCEA1 transcription elongation factor A (SII), 1.
4. Kim B, Nesvizhskii AI, Rani PG, Hahn S, Aebersold R, Ranish JA . The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes . Proceedings of the National Academy of Sciences of the United States of America . 104 . 41 . 16068–73 . October 2007 . 17913884 . 10.1073/pnas.0704573104 . free . 2042163 . 2007PNAS..10416068K .
5. Robinson . Nicholas P. . Fouqueau . Thomas . Blombach . Fabian . Cackett . Gwenny . Carty . Alice E. . Matelska . Dorota M. . Ofer . Sapir . Pilotto . Simona . Phung . Duy Khanh . Werner . Finn . The cutting edge of archaeal transcription . Emerging Topics in Life Sciences . 14 December 2018 . 2 . 4 . 517–533 . 10.1042/ETLS20180014. 33525828 . 7289017 . free .
6. Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J . 6 . FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO . The Journal of Biological Chemistry . 273 . 42 . 27593–601 . October 1998 . 9765293 . 10.1074/jbc.273.42.27593 . free .
7. Pan G, Aso T, Greenblatt J . Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators . The Journal of Biological Chemistry . 272 . 39 . 24563–71 . September 1997 . 9305922 . 10.1074/jbc.272.39.24563 . free .
8. Kettenberger H, Armache KJ, Cramer P . Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage . Cell . 114 . 3 . 347–57 . August 2003 . 12914699 . 10.1016/S0092-8674(03)00598-1 . 11858/00-001M-0000-0015-8647-8 . 17184533 . free .