TC-S 7001 explained

TC-S 7001 (Azaindole-1) is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase, with an IC₅₀ of 0.6 nM at ROCK1 and 1.1 nM at ROCK2.^[1] It has vasodilatory effects and has been used in research for a variety of applications.^{[2] [3] [4]}

See also

• Rho kinase inhibitor

Notes and References

1. Kast R, Schirok H, Figueroa-Pérez S, Mittendorf J, Gnoth MJ, Apeler H, Lenz J, Franz JK, Knorr A, Hütter J, Lobell M, Zimmermann K, Münter K, Augstein KH, Ehmke H, Stasch JP . 6 . Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase . British Journal of Pharmacology . 152 . 7 . 1070–80 . December 2007 . 17934515 . 10.1038/sj.bjp.0707484 . 2095102 .
2. Dahal BK, Kosanovic D, Pamarthi PK, Sydykov A, Lai YJ, Kast R, Schirok H, Stasch JP, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Schermuly RT . 6 . Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension . The European Respiratory Journal . 36 . 4 . 808–18 . October 2010 . 20530035 . 10.1183/09031936.00140309 . 10991200 . free .
3. Pankey EA, Byun RJ, Smith WB, Bhartiya M, Bueno FR, Badejo AM, Stasch JP, Murthy SN, Nossaman BD, Kadowitz PJ . 6 . The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat . Canadian Journal of Physiology and Pharmacology . 90 . 7 . 825–35 . July 2012 . 22591047 . 10.1139/y2012-061 .
4. Lasker GF, Pankey EA, Allain AV, Murthy SN, Stasch JP, Kadowitz PJ . The selective Rho-kinase inhibitor azaindole-1 has long-lasting erectile activity in the rat . Urology . 81 . 2 . 465.e7–14 . February 2013 . 23374844 . 10.1016/j.urology.2012.10.039 . 3564057 .