TBL1X explained

Transducin (beta)-like 1X-linked, also known as TBL1X, is a protein which in humans is encoded by the TBL1X gene.^[1]

Function

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. This gene is highly similar to the Y chromosome TBL1Y gene.^[1]

Interactions

TBL1X has been shown to interact with:

• GPS2, and
• HDAC3,
• NCOA1,^{[2] [3] [4] [5]} and
• NCOA2.^{[3] [4] [5] [6]}

References

Further reading

• Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni M, Townes PL, Beighton P, Ballabio A, Borsani G . X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats . Am. J. Hum. Genet. . 64 . 6 . 1604–16 . 1999 . 10330347 . 1377903 . 10.1086/302408 .
• Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R . A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness . Genes Dev. . 14 . 9 . 1048–57 . 2000 . 10809664 . 316569 . 10.1101/gad.14.9.1048.
• Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J . Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 . EMBO J. . 19 . 16 . 4342–50 . 2000 . 10944117 . 302030 . 10.1093/emboj/19.16.4342 .
• Matsuzawa SI, Reed JC . Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses . Mol. Cell . 7 . 5 . 915–26 . 2001 . 11389839 . 10.1016/S1097-2765(01)00242-8 . free .
• Zhang J, Kalkum M, Chait BT, Roeder RG . The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 . Mol. Cell . 9 . 3 . 611–23 . 2002 . 11931768 . 10.1016/S1097-2765(02)00468-9 . free .
• Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J . Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 . EMBO J. . 22 . 6 . 1336–46 . 2003 . 12628926 . 151047 . 10.1093/emboj/cdg120 .
• Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J . N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso . Mol. Cell . 12 . 3 . 723–34 . 2003 . 14527417 . 10.1016/j.molcel.2003.08.008 . free .
• Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG . A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors . Cell . 116 . 4 . 511–26 . 2004 . 14980219 . 10.1016/S0092-8674(04)00133-3 . 18807923 . free .
• Yoon HG, Choi Y, Cole PA, Wong J . Reading and function of a histone code involved in targeting corepressor complexes for repression . Mol. Cell. Biol. . 25 . 1 . 324–35 . 2005 . 15601853 . 538779 . 10.1128/MCB.25.1.324-335.2005 .
• Gerlitz G, Darhin E, Giorgio G, Franco B, Reiner O . Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization . Cell Cycle . 4 . 11 . 1632–40 . 2005 . 16258276 . 10.4161/cc.4.11.2151 . free .

Notes and References

1. Web site: Entrez Gene: TBL1X transducin (beta)-like 1X-linked.
2. Zhang J, Kalkum M, Chait BT, Roeder RG . The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 . Mol. Cell . 9 . 3 . 611–23 . March 2002 . 11931768 . 10.1016/s1097-2765(02)00468-9. free .
3. Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R . A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness . Genes Dev. . 14 . 9 . 1048–57 . May 2000 . 10809664 . 316569 . 10.1101/gad.14.9.1048.
4. Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J . Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 . EMBO J. . 22 . 6 . 1336–46 . March 2003 . 12628926 . 151047 . 10.1093/emboj/cdg120 .
5. Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J . Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 . EMBO J. . 19 . 16 . 4342–50 . August 2000 . 10944117 . 302030 . 10.1093/emboj/19.16.4342 .
6. Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA . Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex . Genes Dev. . 16 . 24 . 3130–5 . December 2002 . 12502735 . 187500 . 10.1101/gad.1037502 .