TBC1D3 explained

TBC1 domain family member 3E/3F is a protein that in humans is encoded by the TBC1D3F gene.^{[1] [2]}

This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are two copies of this gene located within a cluster of chemokine genes on chromosome 17q; this record represents the more centromeric copy.^[3]

Further reading

• Onno M, Nakamura T, Hillova J, Hill M . Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes. . Gene . 131 . 2 . 209–15 . 1993 . 8406013 . 10.1016/0378-1119(93)90295-E .
• Onno M, Nakamura T, Mariage-Samson R, etal . Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes. . DNA Cell Biol. . 12 . 2 . 107–18 . 1993 . 8471161 . 10.1089/dna.1993.12.107 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Paulding CA, Ruvolo M, Haber DA . The Tre2 (USP6) oncogene is a hominoid-specific gene. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 5 . 2507–11 . 2003 . 12604796 . 10.1073/pnas.0437015100 . 151371 . 2003PNAS..100.2507P . free .
• Masuda-Robens JM, Kutney SN, Qi H, Chou MM . The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. . Mol. Cell. Biol. . 23 . 6 . 2151–61 . 2003 . 12612085 . 10.1128/MCB.23.6.2151-2161.2003 . 149457 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .

Notes and References

1. Hodzic D, Kong C, Wainszelbaum MJ, Charron AJ, Su X, Stahl PD . TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12 . Genomics . 88 . 6 . 731–6 . Nov 2006 . 16863688 . 10.1016/j.ygeno.2006.05.009 .
2. Web site: Entrez Gene: TBC1D3 TBC1 domain family, member 3.
3. Web site: Entrez Gene: TBC1D3 TBC1 domain family, member 3.