Monocarboxylate transporter 10 explained

Monocarboxylate transporter 10 (MCT 10), also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene.^{[1] [2] [3]} SLC16A10 is a member of the solute carrier family.

Function

SLC16A10 mediates Na⁺-independent transport of tryptophan, tyrosine, phenylalanine, and L-DOPA.^[3]

See also

• Blue diaper syndrome

Further reading

• Toure A, Morin L, Pineau C, etal . Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. . J. Biol. Chem. . 276 . 23 . 20309–15 . 2001 . 11278976 . 10.1074/jbc.M011740200 . free .
• Friesema EC, Jansen J, Jachtenberg JW, etal . Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10. . Mol. Endocrinol. . 22 . 6 . 1357–69 . 2008 . 18337592 . 10.1210/me.2007-0112 . 5419535 .
• Loubière LS, Vasilopoulou E, Bulmer JN . Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction. . Placenta . 31 . 4 . 295–304 . 2010 . 20167367 . 10.1016/j.placenta.2010.01.013 . etal . 2019-08-16 . 2021-05-03 . https://web.archive.org/web/20210503101022/https://www.zora.uzh.ch/id/eprint/33687/3/Stieger_TH_transporters-2.pdf . dead .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Bröer S . Amino acid transport across mammalian intestinal and renal epithelia. . Physiol. Rev. . 88 . 1 . 249–86 . 2008 . 18195088 . 10.1152/physrev.00018.2006 . 1834804 .
• Park SY, Kim JK, Kim IJ, etal . Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. . Arch. Pharm. Res. . 28 . 4 . 421–32 . 2005 . 15918515 . 10.1007/BF02977671. 2139640 .
• Halestrap AP, Meredith D . The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. . Pflügers Arch. . 447 . 5 . 619–28 . 2004 . 12739169 . 10.1007/s00424-003-1067-2 . 15498611 .

Notes and References

1. Web site: Entrez Gene: solute carrier family 16.
2. Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H . Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters . J. Biol. Chem. . 276 . 20 . 17221–8 . May 2001 . 11278508 . 10.1074/jbc.M009462200 . free .
3. Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H . The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location . Genomics . 79 . 1 . 95–103 . January 2002 . 11827462 . 10.1006/geno.2001.6678 .