TAS2R9 explained

Taste receptor type 2 member 9 is a protein that in humans is encoded by the TAS2R9 gene.^{[1] [2] [3]}

Function

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.

Polymorphisms in this gene have been associated with the perceived bitterness of sweetener acesulfame potassium.^[4]

See also

• Taste receptor

Further reading

• Kinnamon SC . A plethora of taste receptors . Neuron . 25 . 3 . 507–10 . 2000 . 10774719 . 10.1016/S0896-6273(00)81054-5 . free .
• Margolskee RF . Molecular mechanisms of bitter and sweet taste transduction . J. Biol. Chem. . 277 . 1 . 1–4 . 2002 . 11696554 . 10.1074/jbc.R100054200 . free .
• Montmayeur JP, Matsunami H . Receptors for bitter and sweet taste . Curr. Opin. Neurobiol. . 12 . 4 . 366–71 . 2002 . 12139982 . 10.1016/S0959-4388(02)00345-8 . 37807140 .
• Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ . T2Rs function as bitter taste receptors . Cell . 100 . 6 . 703–11 . 2000 . 10761935 . 10.1016/S0092-8674(00)80706-0 . 7293493 . free .
• Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ . Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways . Cell . 112 . 3 . 293–301 . 2003 . 12581520 . 10.1016/S0092-8674(03)00071-0 . 718601 . free .
• Fischer A, Gilad Y, Man O, Pääbo S . Evolution of bitter taste receptors in humans and apes . Mol. Biol. Evol. . 22 . 3 . 432–6 . 2005 . 15496549 . 10.1093/molbev/msi027 . free .
• Go Y, Satta Y, Takenaka O, Takahata N . Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates . Genetics . 170 . 1 . 313–26 . 2006 . 15744053 . 1449719 . 10.1534/genetics.104.037523 .

Notes and References

1. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS . A novel family of mammalian taste receptors . Cell . 100 . 6 . 693–702 . Apr 2000 . 10761934 . 10.1016/S0092-8674(00)80705-9 . 14604586 . free .
2. Matsunami H, Montmayeur JP, Buck LB . A family of candidate taste receptors in human and mouse . Nature . 404 . 6778 . 601–4 . Apr 2000 . 10766242 . 10.1038/35007072 . 2000Natur.404..601M . 4336913 .
3. Web site: Entrez Gene: TAS2R9 taste receptor, type 2, member 9.
4. Allen AL, McGeary JE, Knopik VS, Hayes JE . Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31 . Chem. Senses . 38 . 5 . 379–89 . 2013 . 23599216 . 3657735 . 10.1093/chemse/bjt017 .