TAS2R50 explained

Taste receptor type 2 member 50 is a protein that in humans is encoded by the TAS2R50 gene.^{[1] [2] [3] [4]}

Function

TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway. See also TAS2R10.

See also

• Taste receptor

Further reading

• Margolskee RF . Molecular mechanisms of bitter and sweet taste transduction . J. Biol. Chem. . 277 . 1 . 1–4 . 2002 . 11696554 . 10.1074/jbc.R100054200 . free .
• Montmayeur JP, Matsunami H . Receptors for bitter and sweet taste . Curr. Opin. Neurobiol. . 12 . 4 . 366–71 . 2002 . 12139982 . 10.1016/S0959-4388(02)00345-8 . 37807140 .
• Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ . Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways . Cell . 112 . 3 . 293–301 . 2003 . 12581520 . 10.1016/S0092-8674(03)00071-0 . 718601 . free .
• Fischer A, Gilad Y, Man O, Pääbo S . Evolution of bitter taste receptors in humans and apes . Mol. Biol. Evol. . 22 . 3 . 432–6 . 2005 . 15496549 . 10.1093/molbev/msi027 . free .
• Go Y, Satta Y, Takenaka O, Takahata N . Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates . Genetics . 170 . 1 . 313–26 . 2006 . 15744053 . 1449719 . 10.1534/genetics.104.037523 .

Notes and References

1. Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W . The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides . Nat Genet . 32 . 3 . 397–401 . Oct 2002 . 12379855 . 10.1038/ng1014 . 20426192 .
2. Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ . Identification and characterization of human taste receptor genes belonging to the TAS2R family . Cytogenet Genome Res . 98 . 1 . 45–53 . Feb 2003 . 12584440 . 10.1159/000068546 . 1542970 .
3. Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP . Identification of Four Gene Variants Associated with Myocardial Infarction . Am J Hum Genet . 77 . 4 . 596–605 . Sep 2005 . 16175505 . 1275608 . 10.1086/491674 .
4. Web site: Entrez Gene: TAS2R50 taste receptor, type 2, member 50.