TAS2R5 explained

Taste receptor type 2 member 5 is a protein that in humans is encoded by the TAS2R5 gene.^[1]

Function

This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception.

See also

• Taste receptor

Further reading

• Kinnamon SC . A plethora of taste receptors. . Neuron . 25 . 3 . 507–10 . 2000 . 10774719 . 10.1016/S0896-6273(00)81054-5 . free .
• Margolskee RF . Molecular mechanisms of bitter and sweet taste transduction. . J. Biol. Chem. . 277 . 1 . 1–4 . 2002 . 11696554 . 10.1074/jbc.R100054200 . free .
• Montmayeur JP, Matsunami H . Receptors for bitter and sweet taste. . Curr. Opin. Neurobiol. . 12 . 4 . 366–71 . 2002 . 12139982 . 10.1016/S0959-4388(02)00345-8 . 37807140 .
• Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS . The receptors and cells for mammalian taste. . Nature . 444 . 7117 . 288–94 . 2007 . 17108952 . 10.1038/nature05401 . 4431221 .
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 16267 . 10.1073/pnas.97.7.3491 . 2000PNAS...97.3491D . free .
• Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS . A novel family of mammalian taste receptors. . Cell . 100 . 6 . 693–702 . 2000 . 10761934 . 10.1016/S0092-8674(00)80705-9 . 14604586 . free .
• Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ . T2Rs function as bitter taste receptors. . Cell . 100 . 6 . 703–11 . 2000 . 10761935 . 10.1016/S0092-8674(00)80706-0 . 7293493 . free .
• Firestein S . The good taste of genomics. . Nature . 404 . 6778 . 552–3 . 2000 . 10766221 . 10.1038/35007167 . 35741332 . free .
• Matsunami H, Montmayeur JP, Buck LB . A family of candidate taste receptors in human and mouse. . Nature . 404 . 6778 . 601–4 . 2000 . 10766242 . 10.1038/35007072 . 2000Natur.404..601M . 4336913 .
• Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ . Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. . Cell . 112 . 3 . 293–301 . 2003 . 12581520 . 10.1016/S0092-8674(03)00071-0 . 718601 . free .
• Fischer A, Gilad Y, Man O, Pääbo S . Evolution of bitter taste receptors in humans and apes. . Mol. Biol. Evol. . 22 . 3 . 432–6 . 2005 . 15496549 . 10.1093/molbev/msi027 . free .
• Go Y, Satta Y, Takenaka O, Takahata N . Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. . Genetics . 170 . 1 . 313–26 . 2006 . 15744053 . 1449719 . 10.1534/genetics.104.037523 .

Notes and References

1. Web site: Entrez Gene: TAS2R5 taste receptor, type 2, member 5.