TAS2R3 explained

Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.^[1]

Function

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.^[1]

Ligands

The only known ligand for TAS2R3 in BitterDB is chloroquine.

See also

• Taste receptor

Further reading

• Kinnamon SC . A plethora of taste receptors . Neuron . 25 . 3 . 507–10 . 2000 . 10774719 . 10.1016/S0896-6273(00)81054-5 . free .
• Margolskee RF . Molecular mechanisms of bitter and sweet taste transduction . J. Biol. Chem. . 277 . 1 . 1–4 . 2002 . 11696554 . 10.1074/jbc.R100054200 . free .
• Montmayeur JP, Matsunami H . Receptors for bitter and sweet taste . Curr. Opin. Neurobiol. . 12 . 4 . 366–71 . 2002 . 12139982 . 10.1016/S0959-4388(02)00345-8 . 37807140 .
• Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS . A novel family of mammalian taste receptors . Cell . 100 . 6 . 693–702 . 2000 . 10761934 . 10.1016/S0092-8674(00)80705-9 . 14604586 . free .
• Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ . T2Rs function as bitter taste receptors . Cell . 100 . 6 . 703–11 . 2000 . 10761935 . 10.1016/S0092-8674(00)80706-0 . 7293493 . free .
• Firestein S . The good taste of genomics . Nature . 404 . 6778 . 552–3 . 2000 . 10766221 . 10.1038/35007167 . 35741332 . free .
• Matsunami H, Montmayeur JP, Buck LB . A family of candidate taste receptors in human and mouse . Nature . 404 . 6778 . 601–4 . 2000 . 10766242 . 10.1038/35007072 . 2000Natur.404..601M . 4336913 .
• Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S . Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting . Biochem. Biophys. Res. Commun. . 285 . 1 . 147–51 . 2001 . 11437385 . 10.1006/bbrc.2001.5136 .
• Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ . Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways . Cell . 112 . 3 . 293–301 . 2003 . 12581520 . 10.1016/S0092-8674(03)00071-0 . 718601 . free .
• Fischer A, Gilad Y, Man O, Pääbo S . Evolution of bitter taste receptors in humans and apes . Mol. Biol. Evol. . 22 . 3 . 432–6 . 2005 . 15496549 . 10.1093/molbev/msi027 . free .
• Go Y, Satta Y, Takenaka O, Takahata N . Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates . Genetics . 170 . 1 . 313–26 . 2006 . 15744053 . 1449719 . 10.1534/genetics.104.037523 .

Notes and References

1. Web site: Entrez Gene: TAS2R3 taste receptor, type 2, member 3.