TAOK2 explained

Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene.^{[1] [2] [3]}

Interactions

TAOK2 has been shown to interact with MAP2K6^[4] and MAP2K3.^[4]

Further reading

• Chen Z, Hutchison M, Cobb MH . Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain . The Journal of Biological Chemistry . 274 . 40 . 28803–28807 . October 1999 . 10497253 . 10.1074/jbc.274.40.28803 . free .
• Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD . PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization . The Journal of Biological Chemistry . 275 . 6 . 4311–4322 . February 2000 . 10660600 . 10.1074/jbc.275.6.4311 . free .
• Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs . Genome Research . 12 . 11 . 1773–1784 . November 2002 . 12421765 . 187542 . 10.1101/gr.406902 .
• Mitsopoulos C, Zihni C, Garg R, Ridley AJ, Morris JD . The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability . The Journal of Biological Chemistry . 278 . 20 . 18085–18091 . May 2003 . 12639963 . 10.1074/jbc.M213064200 . free .
• Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH . TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors . The Journal of Biological Chemistry . 278 . 25 . 22278–22283 . June 2003 . 12665513 . 10.1074/jbc.M301173200 . free .
• Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ . Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38 . Oncogene . 22 . 40 . 6129–6141 . September 2003 . 13679851 . 10.1038/sj.onc.1206605 . free .
• Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J . Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways . The Journal of Biological Chemistry . 281 . 39 . 28802–28810 . September 2006 . 16893890 . 1797068 . 10.1074/jbc.M603627200 . free .
• Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, Morris JD . Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing . The Journal of Biological Chemistry . 282 . 9 . 6484–6493 . March 2007 . 17158878 . 10.1074/jbc.M608336200 . free .
• Wojtala RL, Tavares IA, Morton PE, Valderrama F, Thomas NS, Morris JD . Prostate-derived sterile 20-like kinases (PSKs/TAOKs) are activated in mitosis and contribute to mitotic cell rounding and spindle positioning . The Journal of Biological Chemistry . 286 . 34 . 30161–30170 . August 2011 . 21705329 . 3191055 . 10.1074/jbc.M111.228320 . free .
• de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH . 6 . Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex . Nature Neuroscience . 15 . 7 . 1022–1031 . June 2012 . 22683681 . 4017029 . 10.1038/nn.3141 .
• Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I, Hanger DP, Morris JD . 6 . Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease . The Journal of Biological Chemistry . 288 . 21 . 15418–15429 . May 2013 . 23585562 . 3663559 . 10.1074/jbc.M112.448183 . free .
• Koo CY, Giacomini C, Reyes-Corral M, Olmos Y, Tavares IA, Marson CM, Linardopoulos S, Tutt AN, Morris JD . 6 . Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells . Molecular Cancer Therapeutics . 16 . 11 . 2410–2421 . November 2017 . 28830982 . 10.1158/1535-7163.MCT-17-0077 . free .
• Richter M, Murtaza N, Scharrenberg R, White SH, Johanns O, Walker S, Yuen RK, Schwanke B, Bedürftig B, Henis M, Scharf S, Kraus V, Dörk R, Hellmann J, Lindenmaier Z, Ellegood J, Hartung H, Kwan V, Sedlacik J, Fiehler J, Schweizer M, Lerch JP, Hanganu-Opatz IL, Morellini F, Scherer SW, Singh KK, Calderon de Anda F . 6 . Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling . Molecular Psychiatry . 24 . 9 . 1329–1350 . September 2019 . 29467497 . 6756231 . 10.1038/s41380-018-0025-5 .
• Giacomini C, Koo CY, Yankova N, Tavares IA, Wray S, Noble W, Hanger DP, Morris JD . 6 . A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies . Acta Neuropathologica Communications . 6 . 1 . 37 . May 2018 . 29730992 . 5937037 . 10.1186/s40478-018-0539-8 . free .
• Scharrenberg R, Richter M, Johanns O, Meka DP, Rücker T, Murtaza N, Lindenmaier Z, Ellegood J, Naumann A, Zhao B, Schwanke B, Sedlacik J, Fiehler J, Hanganu-Opatz IL, Lerch JP, Singh KK, de Anda FC . 6 . TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model . Molecular Psychiatry . 27. 11. September 2022 . 4707–4721 . 36123424 . 9734055. 10.1038/s41380-022-01785-3 . 252382956 . free .

Notes and References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . 6 . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 5 . 6 . 355–364 . December 1998 . 10048485 . 10.1093/dnares/5.6.355 . free .
2. Hutchison M, Berman KS, Cobb MH . Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades . The Journal of Biological Chemistry . 273 . 44 . 28625–28632 . October 1998 . 9786855 . 10.1074/jbc.273.44.28625 . free .
3. Web site: Entrez Gene: TAOK2 TAO kinase 2.
4. Chen Z, Cobb MH . Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2 . The Journal of Biological Chemistry . 276 . 19 . 16070–16075 . May 2001 . 11279118 . 10.1074/jbc.M100681200 . free .