TAOK1 explained

Serine/threonine-protein kinase TAO1 is an enzyme that in humans is encoded by the TAOK1 gene.^{[1] [2] [3]}

Clinical significance

Mutations of the TAOK1 gene cause developmental delay with or without intellectual impairment or behavioral abnormalities (DDIB), a condition first described in 2019.

Further reading

• Hutchison M, Berman KS, Cobb MH . Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades . J. Biol. Chem. . 273 . 44 . 28625–32 . 1998 . 9786855 . 10.1074/jbc.273.44.28625 . free .
• Chen Z, Hutchison M, Cobb MH . Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain . J. Biol. Chem. . 274 . 40 . 28803–7 . 1999 . 10497253 . 10.1074/jbc.274.40.28803 . free .
• Dias Neto E, Correa RG, Verjovski-Almeida S, etal . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . 2000PNAS...97.3491D . free .
• Wistow G, Bernstein SL, Wyatt MK, etal . Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants . Mol. Vis. . 8 . 205–20 . 2002 . 12107410 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yustein JT, Xia L, Kahlenburg JM, etal . Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38 . Oncogene . 22 . 40 . 6129–41 . 2003 . 13679851 . 10.1038/sj.onc.1206605 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Lizcano JM, Göransson O, Toth R, etal . LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 . EMBO J. . 23 . 4 . 833–43 . 2005 . 14976552 . 10.1038/sj.emboj.7600110 . 381014 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Zihni C, Mitsopoulos C, Tavares IA, etal . Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1 . J. Biol. Chem. . 281 . 11 . 7317–23 . 2006 . 16407310 . 10.1074/jbc.M513769200 . free .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Raman M, Earnest S, Zhang K, etal . TAO kinases mediate activation of p38 in response to DNA damage . EMBO J. . 26 . 8 . 2005–14 . 2007 . 17396146 . 10.1038/sj.emboj.7601668 . 1852793 .
• Draviam VM, Stegmeier F, Nalepa G, etal . A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling . Nat. Cell Biol. . 9 . 5 . 556–64 . 2007 . 17417629 . 10.1038/ncb1569 . 34976750 .

Notes and References

1. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 7 . 1 . 65–73 . Apr 2000 . 10718198 . 10.1093/dnares/7.1.65 . free .
2. Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J, Mandelkow EM . MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1 . EMBO J . 22 . 19 . 5090–101 . Sep 2003 . 14517247 . 204455 . 10.1093/emboj/cdg447 .
3. Web site: Entrez Gene: TAOK1 TAO kinase 1.