TAN syndrome explained

Field:dermatology

Tegumental angiomyxoma-neurothekeoma (TAN syndrome)[1] is a syndrome, an acronym, and eponym proposed by Malaysian ophthalmologist of Chinese Descent, Tan Aik Kah (b. June 1975).[1] Angiomyxomas are associated with LAMB (lentigines, atrial myxomas, muco-cutaneous myxomas, and blue naevi) syndrome,[2] NAME (nevi, atrial myxoma, myxoid neurofibromas, and ephelides)[3] syndrome and Carney syndrome (atrial, cutaneous and mammary myxomas, lentigines, blue naevi, endocrine disorders and testicular tumours).

TAN syndrome is characterized by multiple superficial angiomyxoma and neurothekeoma confined only to the skin (tegument).[1] TAN syndrome may be used to describe myxomas confined to the skin without visceral involvement.

Case

Tan et al. reported a 10-year-old girl with multiple superficial angiomyxoma associated with neurothekeoma palpebrae.[1] There was no evidence of visceral involvement. The lesions were excised with no recurrence during follow up.[1]

Notes and References

  1. Aik Kah . Tan . Chui Yong . Ku . Annuar . Faridah Hanom . Neurothekeoma palpebrae in association with multiple superficial angiomyxomas: Tegumental Angiomyxoma- Neurothekeoma syndrome (TAN syndrome) . Clinics and Practice . 1 . 3 . e67 . 2011 . 24765328 . 3981382 . 10.4081/cp.2011.e67 .
  2. Rhodes . Arthur R. . Silverman . Robert A. . Harrist . Terence J. . Perez-Atayde . Antonio R. . Mucocutaneous lentigines, cardiomucocutaneous myxomas, and multiple blue nevi: The 'LAMB' syndrome . Journal of the American Academy of Dermatology . 10 . 1 . 72–82 . 1984 . 6693605 . 10.1016/S0190-9622(84)80047-X .
  3. Book: Kamath, Sreenivas . Cardiac Neoplasms . https://books.google.com/books?id=q9WwVCSQmWkC&pg=PA50 . 50–6 . 2006 . Brian P. . Griffin . Curtis M. . Rimmerman . Eric J. . Topol . The Cleveland Clinic Cardiology Board Review . Lippincott Williams & Wilkins . 978-0-7817-5942-7.