TAN-67 explained

TAN-67 (SB-205,607) is an opioid drug used in scientific research that acts as a potent and selective δ-opioid agonist,^[1] selective for the δ₁ subtype.^[2] It has analgesic properties^{[3] [4]} and induces dopamine release in nucleus accumbens.^[5] It also protects both heart and brain tissue from hypoxic tissue damage through multiple mechanisms involving among others an interaction between δ receptors and mitochondrial K(ATP) channels.^{[6] [7] [8] [9] [10]}

Notes and References

1. Fujii H, Kawai K, Kawamura K, Mizusuna A, Onoda Y, Murachi M, Tanaka T, Endoh T, Nagase H . 6 . Synthesis of optically active TAN-67, a highly selective delta opioid receptor agonist, and investigation of its pharmacological properties . Drug Design and Discovery . 17 . 4 . 325–30 . 11765135 . 2001 .
2. Nagase H, Kawai K, Hayakawa J, Wakita H, Mizusuna A, Matsuura H, Tajima C, Takezawa Y, Endoh T . 6 . Rational drug design and synthesis of a highly selective nonpeptide delta-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl- 1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67) . Chemical & Pharmaceutical Bulletin . 46 . 11 . 1695–702 . November 1998 . 9845952 . 10.1248/cpb.46.1695 . free .
3. Yajima Y, Narita M, Tsuda M, Imai S, Kamei J, Nagase H, Suzuki T . Modulation of NMDA- and (+)TAN-67-induced nociception by GABA(B) receptors in the mouse spinal cord . Life Sciences . 68 . 6 . 719–25 . December 2000 . 11205886 . 10.1016/s0024-3205(00)00975-9 .
4. Nagase H, Yajima Y, Fujii H, Kawamura K, Narita M, Kamei J, Suzuki T . The pharmacological profile of delta opioid receptor ligands, (+) and (-) TAN-67 on pain modulation . Life Sciences . 68 . 19–20 . 2227–31 . April 2001 . 11358331 . 10.1016/s0024-3205(01)01010-4 .
5. Fusa K, Takahashi I, Watanabe S, Aono Y, Ikeda H, Saigusa T, Nagase H, Suzuki T, Koshikawa N, Cools AR . 6 . The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals . Neuroscience . 130 . 3 . 745–55 . 15590157 . 10.1016/j.neuroscience.2004.10.016 . 2005 . 42710264 .
6. Fryer RM, Hsu AK, Nagase H, Gross GJ . Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels . The Journal of Pharmacology and Experimental Therapeutics . 294 . 2 . 451–7 . August 2000 . 10900218 .
7. Huh J, Gross GJ, Nagase H, Liang BT . Protection of cardiac myocytes via delta(1)-opioid receptors, protein kinase C, and mitochondrial K(ATP) channels . American Journal of Physiology. Heart and Circulatory Physiology . 280 . 1 . H377-83 . January 2001 . 11123254 . 10.1152/ajpheart.2001.280.1.H377 . 86775469 .
8. Patel HH, Ludwig LM, Fryer RM, Hsu AK, Warltier DC, Gross GJ . Delta opioid agonists and volatile anesthetics facilitate cardioprotection via potentiation of K(ATP) channel opening . FASEB Journal . 16 . 11 . 1468–70 . September 2002 . 12205051 . 10.1096/fj.02-0170fje . free . 22952889 .
9. Maslov LN, Platonov AA, Lasukova TV, Lishmanov I, Oeltgen P, Nagase H, Podoksenov I, Podoksenov AI . 6 . [Delta-opioid receptor activation prevents appearance of irreversible damages of cardiomyocytes and exacerbates myocardial contractility dysfunction during ischemia and reperfusion] . Patologicheskaia Fiziologiia I Eksperimental'naia Terapiia . 4 . 13–7 . 17300082 . 2006 .
10. Tian XS, Zhou F, Yang R, Xia Y, Wu GC, Guo JC . [Effects of intracerebroventricular injection of delta-opioid receptor agonist TAN-67 or antagonist naltrindole on acute cerebral ischemia in rat] . Sheng Li Xue Bao . 60 . 4 . 475–84 . August 2008 . 18690389 .