TAL2 explained
T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.[1] [2]
Function
TAL2 is a member of the basic helix-loop-helix family of transcription factors.[3]
Clinical significance
Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).[2] [4]
Further reading
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Humphray SJ, Oliver K, Hunt AR, etal . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H .
- Marculescu R, Vanura K, Le T, etal . Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL. . Nat. Genet. . 33 . 3 . 342–4 . 2003 . 12567187 . 10.1038/ng1092 . 20213008 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Xia Y, Hwang LY, Cobb MH, Baer R . Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity. . Oncogene . 9 . 5 . 1437–46 . 1994 . 8152805 .
- Wadman I, Li J, Bash RO, etal . Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. . EMBO J. . 13 . 20 . 4831–9 . 1994 . 7957052 . 10.1002/j.1460-2075.1994.tb06809.x. 395422 .
- Xia Y, Brown L, Yang CY, etal . TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. . Proc. Natl. Acad. Sci. U.S.A. . 88 . 24 . 11416–20 . 1992 . 1763056 . 10.1073/pnas.88.24.11416 . 53146 . 1991PNAS...8811416X . free .
- Goldfarb AN, Goueli S, Mickelson D, Greenberg JM . T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein. . Blood . 80 . 11 . 2858–66 . 1992 . 1450410 . 10.1182/blood.V80.11.2858.bloodjournal80112858. free .
Notes and References
- Web site: Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2.
- Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ . TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia . Proc. Natl. Acad. Sci. U.S.A. . 88 . 24 . 11416–20 . December 1991 . 1763056 . 53146 . 10.1073/pnas.88.24.11416. 1991PNAS...8811416X . free .
- Baer R . TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia . Semin. Cancer Biol. . 4 . 6 . 341–7 . December 1993 . 8142619 .
- Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B . Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL . Nat. Genet. . 33 . 3 . 342–4 . March 2003 . 12567187 . 10.1038/ng1092 . 20213008 .
