TAL1 explained

T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene.^{[1] [2]}

The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.

Interactions

TAL1 has been shown to interact with:

• CBFA2T3,
• EP300,^[3]
• GATA1,
• LDB1,^[4]
• LMO1,^{[5] [6]}
• LMO2,^{[4] [7] [5] [6]}
• SIN3A,^[8]
• Sp1 transcription factor,^[9] and
• TCF3.^{[4] [10]}

Further reading

• Green AR, Begley CG . SCL and related hemopoietic helix-loop-helix transcription factors. . Int. J. Cell Cloning . 10 . 5 . 269–76 . 1993 . 1453013 . 10.1002/stem.5530100504 .
• Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD, Kirsch IR . Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia. . Blood . 79 . 5 . 1327–33 . 1992 . 1311214 . 10.1182/blood.V79.5.1327.1327. free .
• Aplan PD, Nakahara K, Orkin SH, Kirsch IR . The SCL gene product: a positive regulator of erythroid differentiation. . EMBO J. . 11 . 11 . 4073–81 . 1992 . 1396592 . 556917 . 10.1002/j.1460-2075.1992.tb05500.x.
• Goldfarb AN, Goueli S, Mickelson D, Greenberg JM . T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein. . Blood . 80 . 11 . 2858–66 . 1992 . 1450410 . 10.1182/blood.V80.11.2858.bloodjournal80112858. 2024-07-25 . free .
• Bernard O, Lecointe N, Jonveaux P, Souyri M, Mauchauffé M, Berger R, Larsen CJ, Mathieu-Mahul D . Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene. . Oncogene . 6 . 8 . 1477–88 . 1991 . 1886719 .
• Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, Berger R, Larsen CJ, Mathieu-Mahul D . Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias. . Genes Chromosomes Cancer . 1 . 3 . 194–208 . 1991 . 1964581 . 10.1002/gcc.2870010303 . 2464453 .
• Chen Q, Yang CY, Tsan JT, Xia Y, Ragab AH, Peiper SC, Carroll A, Baer R . Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. . J. Exp. Med. . 172 . 5 . 1403–8 . 1990 . 2230650 . 2188666 . 10.1084/jem.172.5.1403 .
• Aplan PD, Begley CG, Bertness V, Nussmeier M, Ezquerra A, Coligan J, Kirsch IR . The SCL gene is formed from a transcriptionally complex locus. . Mol. Cell. Biol. . 10 . 12 . 6426–35 . 1991 . 2247063 . 362919 . 10.1128/mcb.10.12.6426.
• Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R . The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. . EMBO J. . 9 . 2 . 415–24 . 1990 . 2303035 . 551682 . 10.1002/j.1460-2075.1990.tb08126.x.
• Begley CG, Aplan PD, Denning SM, Haynes BF, Waldmann TA, Kirsch IR . The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. . Proc. Natl. Acad. Sci. U.S.A. . 86 . 24 . 10128–32 . 1990 . 2602361 . 298658 . 10.1073/pnas.86.24.10128 . free .
• Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH . Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. . Proc. Natl. Acad. Sci. U.S.A. . 92 . 21 . 9585–9 . 1995 . 7568177 . 40846 . 10.1073/pnas.92.21.9585 . 1995PNAS...92.9585O . free .
• Pulford K, Lecointe N, Leroy-Viard K, Jones M, Mathieu-Mahul D, Mason DY . Expression of TAL-1 proteins in human tissues. . Blood . 85 . 3 . 675–84 . 1995 . 7833471 . 10.1182/blood.V85.3.675.bloodjournal853675. free .
• Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R . Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. . EMBO J. . 13 . 20 . 4831–9 . 1994 . 7957052 . 395422 . 10.1002/j.1460-2075.1994.tb06809.x.
• Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH . The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. . Proc. Natl. Acad. Sci. U.S.A. . 91 . 18 . 8617–21 . 1994 . 8078932 . 44657 . 10.1073/pnas.91.18.8617 . 1994PNAS...91.8617V . free .
• Cross MA, Heyworth CM, Murrell AM, Bockamp EO, Dexter TM, Green AR . Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line. . Oncogene . 9 . 10 . 3013–6 . 1994 . 8084606 .
• Hsu HL, Wadman I, Baer R . Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. . Proc. Natl. Acad. Sci. U.S.A. . 91 . 8 . 3181–5 . 1994 . 8159721 . 43539 . 10.1073/pnas.91.8.3181 . 1994PNAS...91.3181H . free .
• Hwang LY, Siegelman M, Davis L, Oppenheimer-Marks N, Baer R . Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen. . Oncogene . 8 . 11 . 3043–6 . 1993 . 8414504 .
• Cheng JT, Cobb MH, Baer R . Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1. . Mol. Cell. Biol. . 13 . 2 . 801–8 . 1993 . 8423803 . 358963 . 10.1128/mcb.13.2.801.

Notes and References

1. Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM . Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma . Proc Natl Acad Sci U S A . 86 . 13 . 5039–43 . August 1989 . 2740341 . 297552 . 10.1073/pnas.86.13.5039 . 1989PNAS...86.5039F . free .
2. Web site: Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1.
3. Huang S, Qiu Y, Stein RW, Brandt SJ . p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein . Oncogene . 18 . 35 . 4958–67 . September 1999 . 10490830 . 10.1038/sj.onc.1202889 . free .
4. Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T . ETO2 coordinates cellular proliferation and differentiation during erythropoiesis . EMBO J. . 25 . 2 . 357–66 . January 2006 . 16407974 . 1383517 . 10.1038/sj.emboj.7600934 .
5. Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH . The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells . Proc. Natl. Acad. Sci. U.S.A. . 91 . 18 . 8617–21 . August 1994 . 8078932 . 44657 . 10.1073/pnas.91.18.8617. 1994PNAS...91.8617V . free .
6. Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R . Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia . EMBO J. . 13 . 20 . 4831–9 . October 1994 . 7957052 . 395422 . 10.1002/j.1460-2075.1994.tb06809.x.
7. Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH . Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1 . Proc. Natl. Acad. Sci. U.S.A. . 92 . 21 . 9585–9 . October 1995 . 7568177 . 40846 . 10.1073/pnas.92.21.9585. 1995PNAS...92.9585O . free .
8. Huang S, Brandt SJ . mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor . Mol. Cell. Biol. . 20 . 6 . 2248–59 . March 2000 . 10688671 . 110841 . 10.1128/mcb.20.6.2248-2259.2000.
9. Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T . The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1 . Blood . 100 . 7 . 2430–40 . October 2002 . 12239153 . 10.1182/blood-2002-02-0568 . free .
10. Hsu HL, Wadman I, Baer R . Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells . Proc. Natl. Acad. Sci. U.S.A. . 91 . 8 . 3181–5 . April 1994 . 8159721 . 43539 . 10.1073/pnas.91.8.3181. 1994PNAS...91.3181H . free .