TAF9B explained

Transcription initiation factor TFIID subunit 9B is a protein that in humans is encoded by the TAF9B gene.^{[1] [2]}

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process.^[3]

Further reading

• Albright SR, Tjian R . TAFs revisited: more data reveal new twists and confirm old ideas . Gene . 242 . 1–2 . 1–13 . 2000 . 10721692 . 10.1016/S0378-1119(99)00495-3 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Ross MT, Grafham DV, Coffey AJ, etal . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Chen Z, Manley JL . In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L . J. Biol. Chem. . 278 . 37 . 35172–83 . 2003 . 12837753 . 10.1074/jbc.M304241200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lu H, Levine AJ . Human TAFII31 protein is a transcriptional coactivator of the p53 protein . Proc. Natl. Acad. Sci. U.S.A. . 92 . 11 . 5154–8 . 1995 . 7761466 . 10.1073/pnas.92.11.5154 . 41867 . 1995PNAS...92.5154L . free .

Notes and References

1. Frontini M, Soutoglou E, Argentini M, Bole-Feysot C, Jost B, Scheer E, Tora L . TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9 . Mol Cell Biol . 25 . 11 . 4638–49 . May 2005 . 15899866 . 1140618 . 10.1128/MCB.25.11.4638-4649.2005 .
2. Web site: Entrez Gene: TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa.
3. Web site: Entrez Gene: TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa.