TAF7L explained
TATA-box binding protein associated factor 7 like is a protein that in humans is encoded by the TAF7L gene.[1]
Function
This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
Further reading
- Stouffs K, Willems A, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I . The role of the testis-specific gene hTAF7L in the aetiology of male infertility . Mol. Hum. Reprod. . 12 . 4 . 263–7 . April 2006 . 16597641 . 10.1093/molehr/gal020 . free .
- Akinloye O, Gromoll J, Callies C, Nieschlag E, Simoni M . Mutation analysis of the X-chromosome linked, testis-specific TAF7L gene in spermatogenic failure . Andrologia . 39 . 5 . 190–5 . October 2007 . 17714218 . 10.1111/j.1439-0272.2007.00789.x . 13317343 .
- Yazarloo F, Shirkoohi R, Mobasheri MB, Emami A, Modarressi MH . Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern . Med. Oncol. . 30 . 1 . 368 . March 2013 . 23292864 . 10.1007/s12032-012-0368-8 . 20377221 .
- Oh HR, An CH, Yoo NJ, Lee SH . Frameshift mutations of TAF7L gene, a core component for transcription by RNA polymerase II, in colorectal cancers . Pathol. Oncol. Res. . 21 . 3 . 849–50 . July 2015 . 25098277 . 10.1007/s12253-014-9832-4 . 15595245 .
Notes and References
- Web site: Entrez Gene: TATA-box binding protein associated factor 7 like. 2018-03-03.