TAF5L explained

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L is an enzyme that in humans is encoded by the TAF5L gene.^{[1] [2] [3]}

Function

The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.^[3]

Interactions

TAF5L has been shown to interact with TAF9^[4] and Transcription initiation protein SPT3 homolog.^[4]

Further reading

• Struhl K, Moqtaderi Z . The TAFs in the HAT . Cell . 94 . 1 . 1–4 . 1998 . 9674419 . 10.1016/S0092-8674(00)81213-1 . 14869072 . free .
• Brand M, Yamamoto K, Staub A, Tora L . Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction . J. Biol. Chem. . 274 . 26 . 18285–9 . 1999 . 10373431 . 10.1074/jbc.274.26.18285 . free .
• Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L . UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation . EMBO J. . 20 . 12 . 3187–96 . 2001 . 11406595 . 150203 . 10.1093/emboj/20.12.3187 .
• Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG . Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo . Mol. Cell. Biol. . 21 . 20 . 6782–95 . 2001 . 11564863 . 99856 . 10.1128/MCB.21.20.6782-6795.2001 .
• Cavusoglu N, Brand M, Tora L, Van Dorsselaer A . Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis . Proteomics . 3 . 2 . 217–23 . 2003 . 12601814 . 10.1002/pmic.200390030 . 6035986 .
• Zhang K, Faiola F, Martinez E . Six lysine residues on c-Myc are direct substrates for acetylation by p300 . Biochem. Biophys. Res. Commun. . 336 . 1 . 274–80 . 2005 . 16126174 . 10.1016/j.bbrc.2005.08.075 .
• Chistiakov DA, Chernisheva A, Savost'anov KV, Turakulov RI, Kuraeva TL, Dedov II, Nosikov VV . The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients . Autoimmunity . 38 . 4 . 283–93 . 2005 . 16206511 . 10.1080/08916930500128594 . 23983176 .
• Kuninger D, Wright A, Rotwein P . Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity . Am. J. Physiol., Cell Physiol. . 291 . 4 . C699-709 . 2006 . 16672693 . 10.1152/ajpcell.00056.2006 .
• Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB . PCAF modulates PTEN activity . J. Biol. Chem. . 281 . 36 . 26562–8 . 2006 . 16829519 . 10.1074/jbc.M605391200 . free .
• Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M . Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression . EMBO J. . 26 . 12 . 2880–9 . 2007 . 17476304 . 1894761 . 10.1038/sj.emboj.7601715 .

Notes and References

1. Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y . Histone-like TAFs within the PCAF histone acetylase complex . Cell . 94 . 1 . 35–44 . Aug 1998 . 9674425 . 10.1016/S0092-8674(00)81219-2 . 18942972 . free .
2. Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G . Characterization of 16 novel human genes showing high similarity to yeast sequences . Yeast . 18 . 1 . 69–80 . Jan 2001 . 11124703 . 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H . 21397515 . free .
3. Web site: Entrez Gene: TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa.
4. Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG . Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo . Mol. Cell. Biol. . 21 . 20 . 6782–95 . Oct 2001 . 11564863 . 99856 . 10.1128/MCB.21.20.6782-6795.2001 .