TAF4B explained

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.^{[1] [2] [3]}

Function

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM]^[3]

Interactions

TAF4B has been shown to interact with RELA.^[4]

Further reading

• Liu WL, Coleman RA, Grob P, King DS, Florens L, Washburn MP, Geles KG, Yang JL, Ramey V, Nogales E, Tjian R . Structural changes in TAF4b-TFIID correlate with promoter selectivity . Mol. Cell . 29 . 1 . 81–91 . 2008 . 18206971 . 2486835 . 10.1016/j.molcel.2007.11.003 .
• Wu Y, Lu Y, Hu Y, Li R . Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line . J. Cell. Biochem. . 96 . 4 . 751–9 . 2005 . 16088961 . 10.1002/jcb.20577 . 23658728 .
• Shao H, Revach M, Moshonov S, Tzuman Y, Gazit K, Albeck S, Unger T, Dikstein R . Core promoter binding by histone-like TAF complexes . Mol. Cell. Biol. . 25 . 1 . 206–19 . 2005 . 15601843 . 538770 . 10.1128/MCB.25.1.206-219.2005 .
• Rashevsky-Finkel A, Silkov A, Dikstein R . A composite nuclear export signal in the TBP-associated factor TAFII105 . J. Biol. Chem. . 276 . 48 . 44963–9 . 2001 . 11567023 . 10.1074/jbc.M106112200 . free .
• Wolstein O, Silkov A, Revach M, Dikstein R . Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription . J. Biol. Chem. . 275 . 22 . 16459–65 . 2000 . 10828057 . 10.1074/jbc.275.22.16459 . free .
• Yamit-Hezi A, Dikstein R . TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB . EMBO J. . 17 . 17 . 5161–9 . 1998 . 9724652 . 1170844 . 10.1093/emboj/17.17.5161 .

Notes and References

1. Dikstein R, Zhou S, Tjian R . Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130 . Cell . 87 . 1 . 137–46 . Nov 1996 . 8858156 . 10.1016/S0092-8674(00)81330-6 . 10194253 . free .
2. Yamit-Hezi A, Nir S, Wolstein O, Dikstein R . Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes . J. Biol. Chem. . 275 . 24 . 18180–7 . Jul 2000 . 10849440 . 10.1074/jbc.275.24.18180 . free .
3. Web site: Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa.
4. Yamit-Hezi A, Dikstein R . TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB . EMBO J. . 17 . 17 . 5161–9 . Sep 1998 . 9724652 . 1170844 . 10.1093/emboj/17.17.5161 .