TAF1B explained

TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene.^{[1] [2]}

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs.

Interactions

TAF1B has been shown to interact with RRN3.^[3]

Further reading

• Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M . Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1 . Cytogenet. Cell Genet. . 89 . 1–2 . 133–6 . 2000 . 10894955 . 10.1159/000015592 . 27014629 .
• Zhai W, Comai L . Repression of RNA polymerase I transcription by the tumor suppressor p53 . Mol. Cell. Biol. . 20 . 16 . 5930–8 . 2000 . 10913176 . 86070 . 10.1128/MCB.20.16.5930-5938.2000 .
• Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC . hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters . EMBO J. . 20 . 6 . 1373–82 . 2001 . 11250903 . 145519 . 10.1093/emboj/20.6.1373 .
• Kim NG, Rhee H, Li LS, Kim H, Lee JS, Kim JH, Kim NK, Kim H . Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability . Oncogene . 21 . 33 . 5081–7 . 2002 . 12140758 . 10.1038/sj.onc.1205703 . free .
• Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I . Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter . EMBO Rep. . 3 . 11 . 1082–7 . 2002 . 12393749 . 1307603 . 10.1093/embo-reports/kvf212 .
• Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ . c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I . Nat. Cell Biol. . 7 . 3 . 311–8 . 2005 . 15723054 . 10.1038/ncb1224 . 8913931 .
• You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, Kim KM, Kim YK, Park SM, Jang SK, Kim H . Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors . PLOS Biol. . 5 . 5 . e109 . 2007 . 17456004 . 1854916 . 10.1371/journal.pbio.0050109 . free .

Notes and References

1. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R . Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits . Science . 266 . 5193 . 1966–72 . January 1995 . 7801123 . 10.1126/science.7801123 . 1994Sci...266.1966C .
2. Web site: Entrez Gene: TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa.
3. Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC . hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters . EMBO J. . 20 . 6 . 1373–82 . March 2001 . 11250903 . 145519 . 10.1093/emboj/20.6.1373 .