TACC3 explained

Transforming acidic coiled-coil-containing protein 3 is a protein that in humans is encoded by the TACC3 gene.^{[1] [2]}

The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice.

Further reading

• Lappin TR, Mullan RN, Stewart JP, etal . AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains . Leuk. Lymphoma . 43 . 7 . 1455–9 . 2003 . 12389629 . 10.1080/1042819022386644 . 2098614 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Still IH, Vince P, Cowell JK . The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines . Genomics . 58 . 2 . 165–70 . 1999 . 10366448 . 10.1006/geno.1999.5829 .
• Gergely F, Karlsson C, Still I, etal . The TACC domain identifies a family of centrosomal proteins that can interact with microtubules . Proc. Natl. Acad. Sci. U.S.A. . 97 . 26 . 14352–7 . 2001 . 11121038 . 10.1073/pnas.97.26.14352 . 18922 . free .
• McKeveney PJ, Hodges VM, Mullan RN, etal . Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells . Br. J. Haematol. . 112 . 4 . 1016–24 . 2001 . 11298601 . 10.1046/j.1365-2141.2001.02644.x . 27869385 .
• Piekorz RP, Hoffmeyer A, Duntsch CD, etal . The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis . EMBO J. . 21 . 4 . 653–64 . 2002 . 11847113 . 10.1093/emboj/21.4.653 . 125348 .
• Steadman BT, Schmidt PH, Shanks RA, etal . Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus . J. Biol. Chem. . 277 . 33 . 30165–76 . 2002 . 12015314 . 10.1074/jbc.M201914200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Sadek CM, Pelto-Huikko M, Tujague M, etal . TACC3 expression is tightly regulated during early differentiation . Gene Expr. Patterns . 3 . 2 . 203–11 . 2004 . 12711550 . 10.1016/S1567-133X(02)00066-2 .
• Leonard D, Ajuh P, Lamond AI, Legerski RJ . hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing . Biochem. Biophys. Res. Commun. . 308 . 4 . 793–801 . 2003 . 12927788 . 10.1016/S0006-291X(03)01486-4 . 10.1.1.539.8359 .
• Gangisetty O, Lauffart B, Sondarva GV, etal . The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases . Oncogene . 23 . 14 . 2559–63 . 2004 . 14767476 . 10.1038/sj.onc.1207424 . 22590391 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .

Notes and References

1. Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nurnberg B, Piekorz RP . The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival . J Biol Chem . 282 . 40 . 29273–83 . Oct 2007 . 17675670 . 10.1074/jbc.M704151200 . free .
2. Web site: Entrez Gene: TACC3 transforming, acidic coiled-coil containing protein 3.