TACC2 explained

Transforming acidic coiled-coil-containing protein 2 is a protein that in humans is encoded by the TACC2 gene.^[1]

Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.^[2]

Further reading

• Still IH, Vince P, Cowell JK . The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. . Genomics . 58 . 2 . 165–70 . 1999 . 10366448 . 10.1006/geno.1999.5829 .
• Still IH, Hamilton M, Vince P, etal . Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. . Oncogene . 18 . 27 . 4032–8 . 1999 . 10435627 . 10.1038/sj.onc.1202801 . free .
• Gergely F, Kidd D, Jeffers K, etal . D–TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo . EMBO J. . 19 . 2 . 241–52 . 2000 . 10637228 . 10.1093/emboj/19.2.241 . 305558 .
• Chen HM, Schmeichel KL, Mian IS, etal . AZU-1: A Candidate Breast Tumor Suppressor and Biomarker for Tumor Progression . Mol. Biol. Cell . 11 . 4 . 1357–67 . 2000 . 10749935 . 10.1091/mbc.11.4.1357. 14852 .
• Gergely F, Karlsson C, Still I, etal . The TACC domain identifies a family of centrosomal proteins that can interact with microtubules . Proc. Natl. Acad. Sci. U.S.A. . 97 . 26 . 14352–7 . 2001 . 11121038 . 10.1073/pnas.97.26.14352 . 18922 . free .
• Pu JJ, Li C, Rodriguez M, Banerjee D . Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells . Cytokine . 13 . 3 . 129–37 . 2001 . 11161455 . 10.1006/cyto.2000.0812 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lauffart B, Gangisetty O, Still IH . Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2 . Genomics . 81 . 2 . 192–201 . 2003 . 12620397 . 10.1016/S0888-7543(02)00039-3 .
• Sadek CM, Pelto-Huikko M, Tujague M, etal . TACC3 expression is tightly regulated during early differentiation . Gene Expr. Patterns . 3 . 2 . 203–11 . 2004 . 12711550 . 10.1016/S1567-133X(02)00066-2 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Deloukas P, Earthrowl ME, Grafham DV, etal . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . free .
• Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P . Structure-function evolution of the Transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms . BMC Evol. Biol. . 4. 16 . 2004 . 15207008 . 10.1186/1471-2148-4-16 . 441373 . free .
• Dou Z, Ding X, Zereshki A, etal . TTK kinase is essential for the centrosomal localization of TACC2 . FEBS Lett. . 572 . 1–3 . 51–6 . 2004 . 15304323 . 10.1016/j.febslet.2004.06.092 . 8403635 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .

Notes and References

1. Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH . The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases . Oncogene . 23 . 14 . 2559–63 . Apr 2004 . 14767476 . 10.1038/sj.onc.1207424 . 22590391 .
2. Web site: Entrez Gene: TACC2 transforming, acidic coiled-coil containing protein 2.