TACC1 explained

Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene.^[1]

Function

The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers.

Interactions

TACC1 has been shown to interact with:

• Aurora A kinase,^{[2] [3]}
• Aurora B kinase,^[2]
• BARD1,^[4]
• CKAP5,^{[3] [5]}
• LSM7,^[3]
• SNRPG,^[6] and
• TDRD7.^[3]

Further reading

• Lappin TR, Mullan RN, Stewart JP, Morgan NA, Thompson A, Maxwell AP . AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains . Leuk. Lymphoma . 43 . 7 . 1455–9 . 2003 . 12389629 . 10.1080/1042819022386644 . 2098614 .
• Still IH, Vince P, Cowell JK . The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines . Genomics . 58 . 2 . 165–70 . 1999 . 10366448 . 10.1006/geno.1999.5829 .
• Still IH, Hamilton M, Vince P, Wolfman A, Cowell JK . Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon . Oncogene . 18 . 27 . 4032–8 . 1999 . 10435627 . 10.1038/sj.onc.1202801 . 24062786 .
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 6 . 3 . 197–205 . 1999 . 10470851 . 10.1093/dnares/6.3.197 . free .
• Gergely F, Karlsson C, Still I, Cowell J, Kilmartin J, Raff JW . The TACC domain identifies a family of centrosomal proteins that can interact with microtubules . Proc. Natl. Acad. Sci. U.S.A. . 97 . 26 . 14352–7 . 2001 . 11121038 . 18922 . 10.1073/pnas.97.26.14352 . free .
• Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH . Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells . Biochem. J. . 363 . Pt 1 . 195–200 . 2002 . 11903063 . 1222467 . 10.1042/0264-6021:3630195 .
• Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC . Serological identification and expression analysis of gastric cancer-associated genes . Br. J. Cancer . 86 . 11 . 1824–30 . 2002 . 12087473 . 2375403 . 10.1038/sj.bjc.6600321 .
• Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D . Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators . Oncogene . 21 . 36 . 5619–30 . 2002 . 12165861 . 10.1038/sj.onc.1205658 . free .
• Line A, Slucka Z, Stengrevics A, Li G, Rees RC . Altered splicing pattern of TACC1 mRNA in gastric cancer . Cancer Genet. Cytogenet. . 139 . 1 . 78–83 . 2003 . 12547166 . 10.1016/S0165-4608(02)00607-6 .
• Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D . TACC1-chTOG-Aurora A protein complex in breast cancer . Oncogene . 22 . 50 . 8102–16 . 2003 . 14603251 . 10.1038/sj.onc.1206972 . 10536264 .
• Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH . The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases . Oncogene . 23 . 14 . 2559–63 . 2004 . 14767476 . 10.1038/sj.onc.1207424 . 22590391 .
• Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D . Aurora B -TACC1 protein complex in cytokinesis . Oncogene . 23 . 26 . 4516–22 . 2004 . 15064709 . 10.1038/sj.onc.1207593 . 23605902 .
• Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P . Structure-function evolution of the Transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms . BMC Evol. Biol. . 4 . 16 . 2004 . 15207008 . 441373 . 10.1186/1471-2148-4-16 . free .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Lauffart B, Dimatteo A, Vaughan MM, Cincotta MA, Black JD, Still IH . Temporal and spatial expression of TACC1 in the mouse and human . Dev. Dyn. . 235 . 6 . 1638–47 . 2007 . 16496324 . 10.1002/dvdy.20724 . 26231825 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Web site: Entrez Gene: TACC1 transforming, acidic coiled-coil containing protein 1.
2. Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D . Aurora B -TACC1 protein complex in cytokinesis . Oncogene . 23 . 26 . 4516–22 . Jun 2004 . 15064709 . 10.1038/sj.onc.1207593 . 23605902 .
3. Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D . TACC1-chTOG-Aurora A protein complex in breast cancer . Oncogene . 22 . 50 . 8102–16 . Nov 2003 . 14603251 . 10.1038/sj.onc.1206972 . 10536264 .
4. Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, Krause KH, Birnbaum D, Irminger-Finger I . Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2 . Cancer Res. . 69 . 3 . 1125–34 . Feb 2009 . 19176389 . 10.1158/0008-5472.CAN-08-2134 . free .
5. Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH . Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells . Biochem. J. . 363 . Pt 1 . 195–200 . Apr 2002 . 11903063 . 1222467 . 10.1042/0264-6021:3630195.
6. Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D . Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators . Oncogene . 21 . 36 . 5619–30 . Aug 2002 . 12165861 . 10.1038/sj.onc.1205658 . free .