TAC4 explained

Tachykinin-4 is a protein that in humans is encoded by the TAC4 gene.^{[1] [2] [3]}

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1 and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Page NM . Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides . Vascul. Pharmacol. . 45 . 4 . 200–8 . 2007 . 16931167 . 10.1016/j.vph.2005.08.028 .
• Page NM . Hemokinins and endokinins . Cell. Mol. Life Sci. . 61 . 13 . 1652–63 . 2004 . 15224188 . 10.1007/s00018-004-4035-x . 31599641 . free . 11138928 .
• Cunningham S . The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis . J. Neuroimmunol. . 183 . 1–2 . 208–13 . 2007 . 17175032 . 10.1016/j.jneuroim.2006.11.002 . vanc. O'Doherty C . Patterson C . 3 . McDonnell . Gavin . Hawkins . Stanley . Marrosu . Marria G. . Vandenbroeck . Koen . 23701000 .
• Page NM . Characterization of the endokinins: Human tachykinins with cardiovascular activity . Proc. Natl. Acad. Sci. U.S.A. . 100 . 10 . 6245–50 . 2003 . 12716968 . 10.1073/pnas.0931458100 . 156357 . vanc. Bell NJ . Gardiner SM . 3 . Manyonda . IT . Brayley . KJ . Strange . PG . Lowry . PJ . 2003PNAS..100.6245P . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Bellucci F . Pharmacological profile of the novel mammalian tachykinin, hemokinin 1 . Br. J. Pharmacol. . 135 . 1 . 266–74 . 2002 . 11786503 . 10.1038/sj.bjp.0704443 . 1573107 . vanc. Carini F . Catalani C . 3 . Cucchi . Paola . Lecci . Alessandro . Meini . Stefania . Patacchini . Riccardo . Quartara . Laura . Ricci . Renzo .
• Dias Neto E . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . vanc. Correa RG . Verjovski-Almeida S . 3 . Briones . MR . Nagai . MA . Da Silva Jr . W . Zago . MA . Bordin . S . Costa . FF . 2000PNAS...97.3491D . free .

Notes and References

1. Zhang Y, Lu L, Furlonger C, Wu GE, Paige CJ . Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis . Nat Immunol . 1 . 5 . 392–7 . Mar 2001 . 11062498 . 10.1038/80826 . 24408728 .
2. Kurtz MM, Wang R, Clements MK, Cascieri MA, Austin CP, Cunningham BR, Chicchi GG, Liu Q . Identification, localization and receptor characterization of novel mammalian substance P-like peptides . Gene . 296 . 1–2 . 205–12 . Oct 2002 . 12383518 . 10.1016/S0378-1119(02)00861-2 .
3. Web site: Entrez Gene: TAC4 tachykinin 4 (hemokinin).