TAAR9 explained

Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene.^{[1] [2]}

TAAR9 is a member of a large family of rhodopsin G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]^[2] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.^{[3] [4]}

TAAR9 gene deletion in rats leads to significantly decreased low-density lipoprotein cholesterol levels in the blood.^[5]

See also

• Trace amine-associated receptor

Further reading

• Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C . 6 . Trace amines: identification of a family of mammalian G protein-coupled receptors . Proceedings of the National Academy of Sciences of the United States of America . 98 . 16 . 8966–71 . July 2001 . 11459929 . 55357 . 10.1073/pnas.151105198 . 2001PNAS...98.8966B . free .
• Vanti WB, Muglia P, Nguyen T, Cheng R, Kennedy JL, George SR, O'Dowd BF . Discovery of a null mutation in a human trace amine receptor gene . Genomics . 82 . 5 . 531–6 . November 2003 . 14559210 . 10.1016/S0888-7543(03)00173-3 .

Notes and References

1. Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC . Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors . Genomics . 85 . 3 . 372–85 . March 2005 . 15718104 . 10.1016/j.ygeno.2004.11.010 .
2. Web site: Entrez Gene: TAAR9 trace amine associated receptor 9.
3. Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, Liberles SD . Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity . ACS Chemical Biology . 7 . 7 . 1184–9 . July 2012 . 22545963 . 3401279 . 10.1021/cb300111e .
4. Liberles SD . Trace amine-associated receptors: ligands, neural circuits, and behaviors . Current Opinion in Neurobiology . 34 . 1–7 . October 2015 . 25616211 . 4508243 . 10.1016/j.conb.2015.01.001 .
5. Murtazina RZ, Zhukov IS, Korenkova OM, Popova EA, Kuvarzin SR, Efimova EV, Kubarskaya LG, Batotsyrenova EG, Zolotoverkhaya EA, Vaganova AN, Apryatin SA, Alenina NV, Gainetdinov RR . 6 . Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels . International Journal of Molecular Sciences . 22 . 6 . March 2021 . 2942 . 33799339 . 7998418 . 10.3390/ijms22062942 . free .