T(11:14) Explained

t(11;14) is a chromosomal translocation which essentially always involves the immunoglobulin heavy locus, also known as IGH in the q32 region of chromosome 14, as well as cyclin D1 which is located in the q13 of chromosome 11 .^[1] Specifically, the translocation is at t(11;14)(q13;q32).^{[2] [3]}

The translocation is mainly found in mantle cell lymphoma, but also in B-cell prolymphocytic leukemia, in plasma cell leukemia, in splenic lymphoma with villous lymphocytes, in chronic lymphocytic leukemia, and in multiple myeloma. All these diseases involve B-lineage lymphocytes.^[1]

Prognosis

In multiple myeloma, t(11;14) is a neutral prognostic factor in general, but it may confer a worse prognosis for overall survival in African American people with multiple myeloma.^[4]

Notes and References

1. Web site: t(11;14)(q13;q32) IGH/CCND1. Jean-Loup Huret. 1998-05-01. Atlas Genet Cytogenet Oncol Haematol..
2. Li JY, Gaillard F, Moreau A, Harousseau JL, Laboisse C, Milpied N, Bataille R, Avet-Loiseau H . 3 . Detection of translocation t(11;14)(q13;q32) in mantle cell lymphoma by fluorescence in situ hybridization . Am. J. Pathol. . 154 . 5 . 1449–52 . May 1999 . 10329598 . 1866594 . 10.1016/S0002-9440(10)65399-0.
3. Barouk-Simonet E, Andrieux J, Copin MC, Grardel-Duflos N, Huyghe P, Patte JH, Preudhomme C, Quesnel B, Laï JL . 3 . TPA stimulation culture for improved detection of t(11;14)(q13;q32) in mantle cell lymphoma . Ann. Genet. . 45 . 3 . 165–8 . 2002 . 12381451 . 10.1016/S0003-3995(02)01122-X.
4. Gasparetto C, Jagannath S, Rifkin RM, Durie BGM, Narang M, Terebelo HR . etal. Effect of t (11;14) Abnormality on Outcomes of Patients With Newly Diagnosed Multiple Myeloma in the Connect MM Registry. . Clin Lymphoma Myeloma Leuk . 2022 . 22 . 3 . 149–157 . 34588149 . 10.1016/j.clml.2021.08.007 . free .