Sylvie Roke Explained

Sylvie Roke
Birth Place:De Bilt, Netherlands
Nationality:Dutch
Known For:Water and Aqueous systems
Hydrophobicity interfacial chemistry
Droplets lipid membranes
Website:https://www.epfl.ch/labs/lbp/
Education:Chemistry
Physics
Alma Mater:Utrecht University
Leiden University
Thesis Title:New light on hidden surfaces
Thesis Url:https://www.differ.nl/node/1295
Thesis Year:2004
Doctoral Advisor:Aart W. Kleyn
Mischa Bonn
Academic Advisors:Alfons van Blaaderen
Albert Polman
Michael Grunze
Discipline:Physics
Chemistry
Sub Discipline:Biophysics
Workplaces:EPFL (École Polytechnique Fédérale de Lausanne)

Sylvie Roke (born 1977 in De Bilt, Netherlands) is a Dutch chemist and physicist specialized in photonics and aqueous systems. As a full professor she holds Julia Jacobi Chair of Photomedicine at EPFL (École Polytechnique Fédérale de Lausanne) and is the director of the Laboratory for fundamental BioPhotonics.[1]

Career

Roke studied chemistry and experimental physics at Utrecht University and graduated in 2000 with honors. Roke studied in Utrecht, graduating from Utrecht University with degrees in chemistry (1995-2000, highest honors) and experimental physics (1997-2000, highest honors). She joined Aart W. Kleyn's Molecular Beams Group at the Institute for Atomic and Molecular Physics (AMOLF) to work on her extended master research project studying the interactions of small molecules with metal surfaces under ultrahigh vacuum conditions.[2] [3] Alfons van Blaaderen (chemistry) and Albert Polman (physics) where her thesis supervisors from Utrecht University. She continued as a PhD student in the Kleyn group moving to Leiden University.[4] In 2004, she graduated with highest honors with thesis co-supervised by Mischa Bonn on "New light on hidden surfaces."[5]

As a postdoctoral student she joined first the FOM Institute for Plasma Physics in Nieuwegein, and thereafter she worked as an Alexander von Humboldt Fellow with Michael Grunze at the Institute of Applied Physical Chemistry at Heidelberg University. In 2005, enabled by a Floating Research Group Leader position and the opportunity to set up her own laboratory from the Max-Planck Society, she moved to the Max Planck Institute for Metals Research in Stuttgart.[6] [7]

In 2011, she joined EPFL first as an assistant professor and was promoted as full professor in 2015.[8] She is the holder of the Julia Jacobi Chair in Photomedicine, and the director of the Laboratory for fundamental BioPhotonics with affiliations both at the Institutes of Bioengineering and Materials (IMX) at the Schools of Engineering and of Life Sciences.[9] [10] In 2021, she became the director of the Institute of Bioengineering.[11] In 2022, she got the Optica Fellow "For pioneering contributions to the theory and practice of nonlinear light scattering and imaging technologies that enable molecular level studies of complex aqueous solutions ".[12]

Research

Roke performs theoretical research and develops non-invasive label-free optical tools for the probing of aqueous systems and interfaces. Her research aims at understanding the properties of water on molecular level in diverse systems such as in aqueous electrolyte and polyelectrolyte solutions, at buried interfaces, in and outside droplets, in curved nanoscale and microscale membranes, in pores and in living cells such as neurons.[13]

To elucidate molecular surface structures, morphologies and chirality of nano- and microscopic objects in solutions, Roke invented vibrational sum frequency scattering (SFS), a method that allows the recording the vibrational spectrum of the molecular interfacial layer around objects.[14] [15] She used SFS to specify the molecular interfaces of complex systems:[16] polymer particles in a solid matrix, particles in solution, oil droplets in water (emulsions),[17] lipid droplet like systems,[18] water droplets,[19] a micro-jet and liposomes in aqueous solution. Her studies indicate that objects on nano- and microscale show different behaviors as model planar interfaces.

Roke has also developed high throughput polarimetric angle resolved second harmonic scattering (AR-SHS), a method allowing for probing particle interfaces and liquids.[20] Making use of non-resonant second harmonic response of water and its response to electrostatic fields, Roke developed a method to determine the surface potential from particle interfaces and the amount of oriented water.[21]

By investigating aqueous solutions, she discovered long-range interactions of ions and water that stem from the influence of the ionic electrostatic field on the water-water hydrogen bonds.[22] Roke found that these interactions are amplified in viscoelastic liquids made of polyelectrolytes such Hyaluronan, and furthermore correlate with the viscosity of such liquids.[23] She developed high-throughput wide field multiphoton microscopy with an about thousand fold increased signal to noise ratio when compared to standard multiphoton confocal imaging systems.[24] A further advantage of this method is a reduction of the photodamage effect in living cells.[25] This allows for the spatiotemporal imaging of interfacial water in various systems: imaging water undergoing surface chemical reactions, electro-catalysis,[26] membrane water and the restructuring of water inside ion channels[27] and activated living mammalian neurons. The latter enables a new way of measuring membrane potentials and ion fluxes in neurons using water as a probe.[28]

Distinctions

Roke is the winner for several ERC grants: ERC Synergy Grant (2020; with Aurélien Roux, University of Geneva),[29] [30] ERC Proof of Concept Grant (2020), ERC Consolidator Grant (2014), ERC Startup Grant (2009)

She is an elected fellow of the American Physical Society (APS; 2020)[31] [32] and of OPTICA (2022).[33] She is a fellow of the Young Academy of the Berlin-Brandenburg Academy of Sciences and Humanities (2010) and the German Academy of Natural Scientists, Leopoldina (2010), a young fellow at the Werner von Siemens Ring, and was selected for the Excellence Network of the Robert-Bosch Foundation.

She is the recipient of the Hertha-Sponer-Preis of the German Physical Society (2008), the Minerva Prize by the Dutch Foundation for Fundamental Research on Matter (2006), and the L. J. Oosterhoff prize by the Leiden University.

Roke has been involved in the creation of the start-up companies ORYL photonics[34] and Matis.[35]

Selected works

External links

Notes and References

  1. Web site: Welcome to LBP!. 2021-03-15. www.epfl.ch. en-GB.
  2. Roke. S.. Coquel. J.M.. Kleyn. A.W.. June 2000. The adsorption behaviour of isobutane on Pt(533): A combined RAIRS and TPD study. Chemical Physics Letters. en. 323. 3–4. 201–208. 10.1016/S0009-2614(00)00528-5. 2000CPL...323..201R .
  3. Web site: Sylvie Roke. EPFL.
  4. Roke. Sylvie. Kleyn. Aart W. Bonn. Mischa. March 2003. Time- vs. frequency-domain femtosecond surface sum frequency generation. Chemical Physics Letters. en. 370. 1–2. 227–232. 10.1016/S0009-2614(03)00085-X. 2003CPL...370..227R .
  5. New light on hidden surfaces. Leiden University. 2004. Leiden, Netherlands. S.. Roke.
  6. Dadap. Jerry I.. de Aguiar. Hilton B.. Roke. Sylvie. 2009-06-07. Nonlinear light scattering from clusters and single particles. The Journal of Chemical Physics. en. 130. 21. 214710. 10.1063/1.3141383. 19508090 . 2009JChPh.130u4710D . 0021-9606.
  7. Web site: Diving into surfaces. 2021-03-22. www.mpg.de. en.
  8. Web site: 14 new professors at the two Federal Institutes of Technology ETH-Board. 2021-03-22. www.ethrat.ch.
  9. Web site: Institute of Bioengineering. 2021-03-22. www.epfl.ch. en-GB.
  10. Web site: Materials - STI - School of Engineering. 2021-03-22. sti.epfl.ch.
  11. Web site: Institute of Bioengineering, EPFL. Reinhard. Dietrich. 2021-01-02. New Directors' Tandem Heading the EPFL's Institute of Bioengineering. en.
  12. Web site: Fellows Search Awards & Honors Optica . 2023-06-26 . www.optica.org.
  13. Okur. Halil I.. Tarun. Orly B.. Roke. Sylvie. 2019-07-19. Chemistry of Lipid Membranes from Models to Living Systems: A Perspective of Hydration, Surface Potential, Curvature, Confinement and Heterogeneity. Journal of the American Chemical Society. 141. 31. 12168–12181. 10.1021/jacs.9b02820. 31323177 . 207196344 . 0002-7863.
  14. Roke. Sylvie. 2009-07-13. Nonlinear Optical Spectroscopy of Soft Matter Interfaces. ChemPhysChem. 10. 9–10. 1380–1388. 10.1002/cphc.200900138. 19472266 . 1439-4235.
  15. de Aguiar. Hilton B.. Samson. Jean-Sebastien. Roke. Sylvie. April 2012. Erratum to: Probing nanoscopic droplet interfaces in aqueous solution with vibrational sum-frequency scattering: A study of the effects of path length, droplet density and pulse energy [Chem. Phys. Lett. 512 (2011) 7680]]. Chemical Physics Letters. 531. 275. 10.1016/j.cplett.2012.01.055. 2012CPL...531..275D . 0009-2614. free.
  16. Book: Johnson. Mark A.. Annual review of physical chemistry. Volume 63, 2012. Martinez. Todd J.. Cremer. Paul S.. Groves. Jay T.. 2012. Annual Reviews. 978-0-8243-1063-9. Palo Alto, Calif.. 819747683.
  17. Zdrali. Evangelia. Chen. Yixing. Okur. Halil I.. Wilkins. David M.. Roke. Sylvie. 2017-12-14. The Molecular Mechanism of Nanodroplet Stability. ACS Nano. 11. 12. 12111–12120. 10.1021/acsnano.7b05100. 29224343 . 1936-0851.
  18. Chen. Yixing. Jena. Kailash C.. Lütgebaucks. Cornelis. Okur. Halil I.. Roke. Sylvie. 2015-07-10. Three Dimensional Nano "Langmuir Trough" for Lipid Studies. Nano Letters. 15. 8. 5558–5563. 10.1021/acs.nanolett.5b02143. 26151602 . 2015NanoL..15.5558C . 1530-6984.
  19. Smolentsev. Nikolay. Smit. Wilbert J.. Bakker. Huib J.. Roke. Sylvie. 2017-05-24. The interfacial structure of water droplets in a hydrophobic liquid. Nature Communications. 8. 1. 15548 . 10.1038/ncomms15548. 28537259 . 5458086 . 2017NatCo...815548S . 2041-1723. free.
  20. Gomopoulos. Nikolaos. Lütgebaucks. Cornelis. Sun. Qinchao. Macias-Romero. Carlos. Roke. Sylvie. 2013-01-08. Label-free second harmonic and hyper Rayleigh scattering with high efficiency. Optics Express. 21. 1. 815–821. 10.1364/oe.21.000815. 23388974 . 2013OExpr..21..815G . 1094-4087. free.
  21. Lütgebaucks. Cornelis. Gonella. Grazia. Roke. Sylvie. 2016-11-10. Optical label-free and model-free probe of the surface potential of nanoscale and microscopic objects in aqueous solution. Physical Review B. 94. 19. 195410 . 10.1103/physrevb.94.195410. 2016PhRvB..94s5410L . 2469-9950.
  22. Chen. Yixing. Okur. Halil I.. Gomopoulos. Nikolaos. Macias-Romero. Carlos. Cremer. Paul S.. Petersen. Poul B.. Tocci. Gabriele. Wilkins. David M.. Liang. Chungwen. Ceriotti. Michele. Roke. Sylvie. April 2016. Electrolytes induce long-range orientational order and free energy changes in the H-bond network of bulk water. Science Advances. 2. 4. e1501891. 10.1126/sciadv.1501891. 27152357 . 4846452 . 2016SciA....2E1891C . 2375-2548. free.
  23. Dedic. J.. Okur. H. I.. Roke. S.. December 2019. Polyelectrolytes induce water-water correlations that result in dramatic viscosity changes and nuclear quantum effects. Science Advances. en. 5. 12. eaay1443. 10.1126/sciadv.aay1443. 32064319 . 6989307. 2019SciA....5.1443D . 2375-2548. free.
  24. Macias-Romero. Carlos. Nahalka. Igor. Okur. Halil I.. Roke. Sylvie. 2017-07-20. Optical imaging of surface chemistry and dynamics in confinement. Science. 357. 6353. 784–788. 10.1126/science.aal4346. 28729352 . 0036-8075. free. 1707.00590.
  25. Macias-Romero. C.. Zubkovs. V.. Wang. S.. Roke. S.. 2016-03-24. Wide-field medium-repetition-rate multiphoton microscopy reduces photodamage of living cells. Biomedical Optics Express. 7. 4. 1458–1467. 10.1364/boe.7.001458. 27446668 . 4929654 . 2156-7085. free.
  26. Zwaschka. Gregor. Nahalka. Igor. Marchioro. Arianna. Tong. Yujin. Roke. Sylvie. Campen. R. Kramer. 2020-04-30. Imaging the Heterogeneity of the Oxygen Evolution Reaction on Gold Electrodes Operando: Activity is Highly Local. ACS Catalysis. 10. 11. 6084–6093. 10.1021/acscatal.0c01177. 32551180 . 7295367. 2155-5435. free.
  27. Tarun. Orly B.. Eremchev. Maksim Yu.. Radenovic. Aleksandra. Roke. Sylvie. 2019-10-03. Spatiotemporal Imaging of Water in Operating Voltage-Gated Ion Channels Reveals the Slow Motion of Interfacial Ions. Nano Letters. 19. 11. 7608–7613. 10.1021/acs.nanolett.9b02024. 31580677 . 2019NanoL..19.7608T . 203661186 . 1530-6984.
  28. Didier. M. E. P.. Tarun. O. B.. Jourdain. P.. Magistretti. P.. Roke. S.. December 2018. Membrane water for probing neuronal membrane potentials and ionic fluxes at the single cell level. Nature Communications. 9. 1. 5287 . 10.1038/s41467-018-07713-w. 30538243 . 6289965 . 2018NatCo...9.5287D . 2041-1723. free.
  29. Web site: ERC-Grant-Roux-Roke. 2021-03-23. NCCR in Chemical Biology. en-US.
  30. Web site: Zoom sur les flux d'eau cellulaires-Brèves-Lʹisolement en psychiatrie-La fabrication du vin sous surveillance chimique - Radio. 2021-03-23. Play RTS. 9 November 2020 . fr.
  31. Web site: Home - Unit - DCP. 2021-03-23. engage.aps.org. en.
  32. Web site: Basic Sciences, EPFL. Papageorgiou. Nik. 2020-01-10. Suliana Manley and Sylvie Roke elected APS Fellows. en.
  33. Web site: Fellows Search Awards & Honors Optica . 2023-06-26 . www.optica.org.
  34. Web site: ORYL Photonics Light for Life. 2021-03-23. ORYL Photonics. en-US.
  35. Web site: Startups developing a software to automate brain tumor detection, suspended drones for harvesting, innovative spinal care, an IR camera for authentication of artworks, and next generation cancer diagnostic and monitoring each win CHF 10,000. 2021-03-23. www.venturekick.ch. en.

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