Sylvain Guillaume (born 6 July 1968 in Champagnole, Jura) is a former French nordic combined skier who competed during the 1990s. At the 1992 Winter Olympics in Albertville he won a silver in the 15 km individual, then a bronze in the 4 x 5 km team competition at the 1998 Winter Olympics in Nagano. He also won a bronze medal in the 15 km individual at the 1995 FIS Nordic World Ski Championships in Thunder Bay, Ontario.