| Event: | Women's 4 × 100 metre medley relay |
| Games: | 2022 |
| Venue: | Sandwell Aquatics Centre |
| Dates: | 3 August |
| Competitors: | 24 |
| Nations: | 6 |
| Win Value: | 3:54.44 |
| Gold: | Kaylee McKeown Chelsea Hodges Emma McKeon Mollie O'Callaghan |
| Goldcga: | AUS |
| Silver: | Kylie Masse Sophie Angus Maggie Mac Neil Summer McIntosh |
| Silvercga: | CAN |
| Bronze: | Lauren Cox Molly Renshaw Laura Stephens Anna Hopkin |
| Bronzecga: | ENG |
| Prev: | 2018 |
| Next: | 2026 |
The women's 4 × 100 metre medley relay event at the 2022 Commonwealth Games was held on 3 August at the Sandwell Aquatics Centre.
Prior to this competition, the existing world, Commonwealth and Games records were as follows:
The schedule is as follows:[1]
All times are British Summer Time (UTC+1)
| Rank | Lane | Nation | Swimmers | Time | Notes |
|---|---|---|---|---|---|
| 5 | Kaylee McKeown (58.79) Chelsea Hodges (1:06.68) Emma McKeon (56.59) Mollie O'Callaghan (52.38) | 3:54.44 | |||
| 4 | Kylie Masse (59.01) Sophie Angus (1:07.66) Maggie Mac Neil (56.59) Summer McIntosh (53.33) | 3:56.59 | |||
| 3 | Lauren Cox (1:00.72) Molly Renshaw (1:06.61) Laura Stephens (58.96) Anna Hopkin (53.15) | 3:59.44 | |||
| 4 | 6 | Rebecca Meder (1:01.39) Lara van Niekerk (1:05.56) Erin Gallagher (58.88) Aimee Canny (53.80) | 3:59.63 | AF | |
| 5 | 2 | Katie Shanahan (1:02.27) Kara Hanlon (1:07.54) Keanna Macinnes (1:00.07) Lucy Hope (54.95) | 4:04.83 | NR | |
| 6 | 7 | Tatiana Tostevin (1:05.27) Laura le Cras (1:14.82) Orla Rabey (1:02.36) Molly Staples (1:00.92) | 4:23.37 | ||