| Event: | Mixed 4×100 metre medley relay |
| Games: | 2015 African Games |
| Dates: | 10 September 2015 |
| Venue: | Kintele Aquatic Complex |
| Location: | Brazzaville, Republic of the Congo |
| Competitors: | 32 |
| Nations: | 8 |
| Win Value: | 3:31.56 |
| Gold: | Mohamed Samy Youssef El-Kamash Farida Osman Rowan El Badry |
| Gold Nation: | EGY |
| Silver: | Jessica Ashley-Cooper Alaric Basson Nico Meyer Karin Prinsloo |
| Silver Nation: | RSA |
| Bronze: | Kirsty Coventry James Lawson Tarryn Rennie Sean Gunn |
| Bronze Nation: | ZIM |
See main article: Swimming at the 2015 African Games.
The 4×100 metre medley mixed event at the 2015 African Games took place on 10 September 2015 at Kintele Aquatic Complex.
All times are Congo Standard Time
| width=220 | Date | width=50 | Time | width=100 | Event |
|---|---|---|---|---|---|
| Thursday, 10 September 2015 | 19:10 | Final |
| Rank | Lane | Nation | Swimmers | Time | Notes | |
|---|---|---|---|---|---|---|
| 5 | Mohamed Samy (57.28) Youssef El-Kamash (1:02.67) Farida Osman (59.27) Rowan El Badry (56.82) | 3:56.04 | GR | |||
| 4 | Jessica Ashley-Cooper (1:03.79) Alaric Basson (1:03.04) Nico Meyer (54.63) Karin Prinsloo (54.81) | 3:56.27 | ||||
| 1 | Kirsty Coventry (1:02.10) James Lawson (1:02.92) Tarryn Rennie (1:05.08) Sean Gunn (50.68) | 4:00.78 | ||||
| 4 | 6 | Rim Ouennich (1:05.37) Wassim Elloumi (1:02.96) Asma Sammoud (1:03.60) Mohamed Mehdi Laagili (51.48) | 4:03.41 | |||
| 5 | 2 | Riyad Djendouci (58.97) Abdelkader Afane (1:04.36) Hamida Rania Nefsi (1:05.52) Majda Chebaraka (59.24) | 4:08.09 | |||
| 6 | 3 | Hamdan Bayusuf (1:00.91) Rebecca Kamau (1:12.38) Issa Abdellah (58.73) Sylvia Brunlehner (59.86) | 4:11.88 | |||
| 7 | 8 | Samson Opuakpo (1:02.39) Racheal Tonjor (1:22.32) Ifeakachukwu Nmor (57.16) Ifiezibe Gagbe (1:02.74) | 4:24.61 | |||
| 8 | 7 | Igor Mogne (1:01.54) Valdo Lourecon (1:13.72) Gessica Stagno (1:07.26) Gisela Cossa (1:05.63) | 4:28.15 |