| Event: | Mixed 4×100 metre freestyle relay |
| Games: | 2015 African Games |
| Dates: | 7 September 2015 |
| Venue: | Kintele Aquatic Complex |
| Location: | Brazzaville, Republic of the Congo |
| Competitors: | 32 |
| Nations: | 8 |
| Win Value: | 3:31.56 |
| Gold: | Chad le Clos Clayton Jimmie Marlies Ross Karin Prinsloo |
| Gold Nation: | RSA |
| Silver: | Rowan El Badry Mohammed Khaled Farida Osman Mohamed Samy |
| Silver Nation: | EGY |
| Bronze: | Nazim Belkhodja Souad Nafissa Cherouati Badis Djendouci Majda Chebaraka |
| Bronze Nation: | ALG |
See main article: Swimming at the 2015 African Games.
The 4×100 metre freestyle mixed event at the 2015 African Games took place on 7 September 2015 at Kintele Aquatic Complex.
All times are Congo Standard Time
| width=220 | Date | width=50 | Time | width=100 | Event |
|---|---|---|---|---|---|
| Monday, 7 September 2015 | 18:46 | Final |
| Rank | Lane | Nation | Swimmers | Time | Notes | |
|---|---|---|---|---|---|---|
| 4 | Chad le Clos (48.50) Clayton Jimmie (50.22) Marlies Ross (57.10) Karin Prinsloo (55.74) | 3:31.56 | GR | |||
| 5 | Rowan El Badry (56.71) Mohammed Khaled (50.69) Farida Osman (55.69) Mohamed Samy (49.43) | 3:32.52 | ||||
| 6 | Nazim Belkhodja (50.70) Souad Nafissa Cherouati (58.36) Badis Djendouci (52.25) Majda Chebaraka (59.62) | 3:40.93 | ||||
| 4 | 3 | Farah Ben Khelil (59.24) Mohamed Ali Chaouachi (52.09) Rim Ouennich (58.38) Mohamed Mehdi Laagili (51.47) | 3:41.18 | |||
| 5 | 8 | Peter Wetzlar (52.89) Tarryn Rennie (1:00.53) Kirsty Coventry (57.91) Sean Gunn (50.72) | 3:42.05 | NR | ||
| 6 | 2 | Bradley Vincent (51.37) Olivia De Maroussem (1:01.31) Heather Arseth (58.35) Mathieu Marquet (51.86) | 3:42.89 | |||
| 7 | 1 | Edward Ilako (54.99) Sylvia Brunlehner (59.67) Emily Muteti (1:01.80) Issa Abdellah (53.40) | 3:49.86 | |||
| 8 | 7 | Igor Mogne (52.39) Denilson da Costa (55.09) Gessica Stagno (1:03.12) Gisela Cossa (1:05.33) | 3:55.93 |