| Event: | Women's 50 metre freestyle S5 |
| Games: | 2012 Summer |
| Venue: | London Aquatics Centre |
| Dates: | 30 August |
| Competitors: | 11 |
| Nations: | 10 |
| Gold: | Nataliia Prologaieva |
| Goldnpc: | UKR |
| Silver: | Teresa Perales |
| Silvernpc: | ESP |
| Bronze: | Inbal Pezaro |
| Bronzenpc: | ISR |
The women's 50 metre freestyle S5 event at the 2012 Paralympic Games took place on 30 August, at the London Aquatics Centre.
Two heats were held, one with six swimmers and one with five swimmers. The swimmers with the eight fastest times advanced to the final.
| Rank | Heat | Lane | Name | Nationality | Time | Notes | |
|---|---|---|---|---|---|---|---|
| 1 | 2 | 4 | Nataliia Prologaieva | 36.43 | Q | ||
| 2 | 1 | 4 | Teresa Perales | 37.06 | Q | ||
| 3 | 1 | 5 | Joana Maria Silva | 38.73 | Q | ||
| 4 | 1 | 3 | Viktoriia Savtsova | 39.12 | Q | ||
| 5 | 2 | 3 | Inbal Pezaro | 39.74 | Q | ||
| 6 | 2 | 7 | Katalin Engelhardt | 43.94 | Q | ||
| 7 | 2 | 6 | Simone Fragoso | 44.49 | Q | ||
| 8 | 1 | 6 | Lisette Teunissen | 46.63 | Q | ||
| 9 | 1 | 2 | Alyssa Gialamas | 47.08 | |||
| 10 | 2 | 2 | Rui Si Theresa Goh | 47.91 | |||
| – | 2 | 5 | Anita Fatis |
| Rank | Lane | Name | Nationality | Time | Notes | |
|---|---|---|---|---|---|---|
| 4 | Nataliia Prologaieva | 35.88 | =WR | |||
| 5 | Teresa Perales | 36.50 | ||||
| 2 | Inbal Pezaro | 37.89 | ||||
| 4 | 3 | Joana Maria Silva | 38.11 | AM | ||
| 5 | 6 | Viktoriia Savtsova | 38.50 | |||
| 6 | 7 | Katalin Engelhardt | 44.06 | |||
| 7 | 1 | Simone Fragoso | 44.78 | |||
| 8 | 8 | Lisette Teunissen | 44.82 | PR |