| Event: | Women's 100 metre Breaststroke SB4 |
| Games: | 2012 Summer |
| Venue: | London Aquatics Centre |
| Dates: | 4 September |
| Competitors: | 12 |
| Nations: | 11 |
| Gold: | Nataliia Prologaieva |
| Goldnpc: | UKR |
| Silver: | Sarah Louise Rung |
| Silvernpc: | NOR |
| Bronze: | Teresa Perales |
| Bronzenpc: | ESP |
The women's 100 metre breaststroke SB4 event at the 2012 Paralympic Games took place on 4 September, at the London Aquatics Centre.
Two heats were held, both with six swimmers. The swimmers with the eight fastest times advanced to the final.
| Rank | Lane | Name | Nationality | Time | Notes |
|---|---|---|---|---|---|
| 1 | 4 | Nataliia Prologaieva | 1:44.90 | Q, WR | |
| 2 | 5 | Inbal Pezaro | 1:57.95 | Q | |
| 3 | 6 | Chrysoula Antoniadou | 2:04.56 | Q | |
| 4 | 3 | Alice Hsiao Hung Luo | 2:06.80 | Q | |
| 5 | 2 | Katalin Engelhardt | 2:10.53 | ||
| 6 | 7 | Naiver Ome Ramos | 2:20.51 | ||
| Rank | Lane | Name | Nationality | Time | Notes |
|---|---|---|---|---|---|
| 1 | 4 | Sarah Louise Rung | 1:45.58 | Q | |
| 2 | 5 | Teresa Perales | 1:56.90 | Q | |
| 3 | 3 | Natalia Shavel | 2:04.55 | Q | |
| 4 | 2 | Qi Wu | 2:10.31 | Q | |
| 5 | 6 | Natalia Gavrilyuk | 2:14.76 | ||
| 6 | 7 | Lorena Homar Lopez | 2:18.19 | ||
| Rank | Lane | Name | Nationality | Time | Notes | |
|---|---|---|---|---|---|---|
| 4 | Nataliia Prologaieva | 1:43.99 | WR | |||
| 5 | Sarah Louise Rung | 1:45.68 | ||||
| 3 | Teresa Perales | 1:56.17 | ||||
| 4 | 6 | Inbal Pezaro | 1:56.73 | |||
| 5 | 2 | Natalia Shavel | 2:00.03 | |||
| 6 | 7 | Chrysoula Antoniadou | 2:03.80 | |||
| 7 | 1 | Alice Hsiao Hung Luo | 2:06.05 | |||
| 8 | 8 | Qi Wu | 2:09.70 |