| Event: | Men's 50 metre freestyle S2 |
| Games: | 2012 Summer |
| Venue: | London Aquatics Centre |
| Dates: | 7 September |
| Competitors: | 12 |
| Nations: | 9 |
| Gold: | Yang Yang |
| Goldnpc: | CHN |
| Silver: | Dmitrii Kokarev |
| Silvernpc: | RUS |
| Bronze: | Aristeidis Makrodimitris |
| Bronzenpc: | GRE |
The men's 50 metre freestyle S2 event at the 2012 Paralympic Games took place on 7 September, at the London Aquatics Centre.
Two heats were held, both with six swimmers. The swimmers with the eight fastest times advanced to the final.
| Rank | Lane | Name | Nationality | Time | Notes |
|---|---|---|---|---|---|
| 1 | 4 | Aristeidis Makrodimitris | 1:06.69 | Q | |
| 2 | 3 | Iad Josef Shalabi | 1:07.52 | Q | |
| 3 | 5 | Jacek Czech | 1:07.56 | Q | |
| 4 | 6 | Curtis Lovejoy | 1:10.44 | Q | |
| 5 | 2 | Francesco Bettella | 1:13.86 | ||
| 7 | Christos Tampaxis | DNS | |||
| Rank | Lane | Name | Nationality | Time | Notes |
|---|---|---|---|---|---|
| 1 | 7 | Yang Yang | 1:01.05 | Q | |
| 2 | 4 | Dmitrii Kokarev | 1:05.61 | Q | |
| 3 | 6 | Ievgen Panibratets | 1:08.45 | Q | |
| 4 | 5 | Itzhak Mamistvalov | 1:08.73 | Q | |
| 5 | 2 | Georgios Kapellakis | 1:10.48 | ||
| 6 | 3 | James Anderson | 1:10.61 | ||
| Rank | Lane | Name | Nationality | Time | Notes | |
|---|---|---|---|---|---|---|
| 4 | Yang Yang | 1:01.39 | ||||
| 5 | Dmitrii Kokarev | 1:02.47 | ||||
| 3 | Aristeidis Makrodimitris | 1:04.86 | ||||
| 4 | 2 | Jacek Czech | 1:06.41 | |||
| 5 | 6 | Iad Josef Shalabi | 1:07.07 | |||
| 6 | 1 | Itzhak Mamistvalov | 1:07.94 | |||
| 7 | 7 | Ievgen Panibratets | 1:08.75 | |||
| 8 | 8 | Curtis Lovejoy | 1:13.45 |