| Event: | Women's 100 metre freestyle S5 |
| Games: | 2012 Summer |
| Venue: | London Aquatics Centre |
| Dates: | 8 September |
| Competitors: | 11 |
| Nations: | 10 |
| Gold: | Teresa Perales |
| Goldnpc: | ESP |
| Silver: | Nataliia Prologaieva |
| Silvernpc: | UKR |
| Bronze: | Inbal Pezaro |
| Bronzenpc: | ISR |
The women's 100 metre freestyle S5 event at the 2012 Paralympic Games took place on 8 September, at the London Aquatics Centre.
Two heats were held, one with six swimmers and one with five swimmers. The swimmers with the eight fastest times advanced to the final.
| Rank | Lane | Name | Nationality | Time | Notes |
|---|---|---|---|---|---|
| 1 | 4 | Sarah Louise Rung | 1:23.98 | Q | |
| 2 | 5 | Inbal Pezaro | 1:25.91 | Q | |
| 3 | 6 | Viktoriia Savtsova | 1:26.90 | Q | |
| 4 | 3 | Joana Maria Silva | 1:28.90 | Q | |
| 5 | 2 | Simone Fragoso | 1:41.56 | ||
| Rank | Lane | Name | Nationality | Time | Notes |
|---|---|---|---|---|---|
| 1 | 5 | Nataliia Prologaieva | 1:20.62 | Q | |
| 2 | 4 | Teresa Perales | 1:23.39 | Q | |
| 3 | 3 | Anita Fatis | 1:25.05 | Q | |
| 4 | 7 | Katalin Engelhardt | 1:36.23 | Q | |
| 5 | 2 | Alyssa Gialamas | 1:40.23 | ||
| 6 | 6 | Rui Si Theresa Goh | 1:45.78 | ||
| Rank | Lane | Name | Nationality | Time | Notes | |
|---|---|---|---|---|---|---|
| 5 | Teresa Perales | 1:18.55 | ||||
| 4 | Nataliia Prologaieva | 1:20.57 | ||||
| 2 | Inbal Pezaro | 1:22.56 | ||||
| 4 | 3 | Sarah Louise Rung | 1:23.15 | |||
| 5 | 6 | Anita Fatis | 1:24.34 | |||
| 6 | 7 | Viktoriia Savtsova | 1:26.82 | |||
| 7 | 1 | Joana Maria Silva | 1:29.28 | |||
| 8 | 8 | Katalin Engelhardt | 1:36.91 |