| Event: | Men's 100 metre freestyle S2 |
| Games: | 2012 Summer |
| Venue: | London Aquatics Centre |
| Dates: | 3 September |
| Competitors: | 12 |
| Nations: | 9 |
| Gold: | Yang Yang |
| Goldnpc: | CHN |
| Silver: | Dmitrii Kokarev |
| Silvernpc: | RUS |
| Bronze: | Aristeidis Makrodimitris |
| Bronzenpc: | GRE |
The men's 100 metre freestyle S2 event at the 2012 Paralympic Games took place on 3 September, at the London Aquatics Centre.
Two heats were held, both with six swimmers. The swimmers with the eight fastest times advanced to the final.
| Rank | Lane | Name | Nationality | Time | Notes |
|---|---|---|---|---|---|
| 1 | 4 | Dmitrii Kokarev | 2:18.30 | Q | |
| 2 | 5 | Itzhak Mamistvalov | 2:26.55 | Q | |
| 3 | 3 | Jacek Czech | 2:27.14 | Q | |
| 4 | 2 | Denys Zhumela | 2:33.86 | ||
| 5 | 6 | Curtis Lovejoy | 2:37.15 | ||
| 6 | 7 | Ievgen Panibratets | 2:38.48 | ||
| Rank | Lane | Name | Nationality | Time | Notes |
|---|---|---|---|---|---|
| 1 | 4 | Yang Yang | 2:10.47 | Q, WR | |
| 2 | 5 | Aristeidis Makrodimitris | 2:21.99 | Q | |
| 3 | 2 | Iad Josef Shalabi | 2:25.55 | Q | |
| 4 | 3 | James Anderson | 2:27.43 | Q | |
| 5 | 6 | Francesco Bettella | 2:29.34 | Q | |
| 6 | 7 | Georgios Kapellakis | 2:46.18 | ||
| Rank | Lane | Name | Nationality | Time | Notes | |
|---|---|---|---|---|---|---|
| 4 | Yang Yang | 2:03.71 | WR | |||
| 5 | Dmitrii Kokarev | 2:16.46 | ||||
| 3 | Aristeidis Makrodimitris | 2:21.04 | ||||
| 4 | 7 | Jacek Czech | 2:22.84 | |||
| 5 | 6 | Iad Josef Shalabi | 2:24.73 | |||
| 6 | 2 | Itzhak Mamistvalov | 2:25.60 | |||
| 7 | 8 | Francesco Bettella | 2:31.17 | |||
| 8 | 1 | James Anderson | 2:31.33 |