The Women's 4 × 100 metre freestyle relay event at the 2010 Commonwealth Games took place on 8 October 2010, at the SPM Swimming Pool Complex.[1]
A final was held only, containing eight countries.[1]
| Rank | Lane | Names | Time | Notes | |
|---|---|---|---|---|---|
| 4 | Alicia Coutts (54.17) Marieke Guehrer (54.08) Felicity Galvez (53.98) Emily Seebohm (54.13) | 3:36.36 | |||
| 5 | Amy Smith (55.26) Francesca Halsall (53.98) Emma Saunders (55.51) Jessica Sylvester (55.28) | 3:40.03 | |||
| 6 | Hayley Palmer (55.11) Penelope Marshall (55.76) Amaka Gessler (55.79) Natasha Hind (55.46) | 3:42.12 | NR | ||
| 4 | 2 | Sycerika McMahon (57.46) Clare Dawson (58.26) Bethany Carson (57.06) Melanie Nocher (56.70) | 3:49.48 | ||
| 5 | 7 | Caitlin McClatchey (56.88) Sara Hamilton (57.53) Megan Gilchrist (58.66) Lucy Ellis (56.72) | 3:49.79 | ||
| 6 | 1 | Kah Chan (58.47) Lai Chui (57.27) Chii Leung (58.70) Cai Khoo (1:00.39) | 3:54.83 | ||
| 7 | 8 | Talasha Prabhu (59.96) Sneha Thirugnanasambandam (1:02.31) Surabhi Tipre (1:00.75) Jyotsna Pansare (59.53) | 4:02.55 | ||
| 8 | 3 | Victoria Poon (55.34) Geneviève Saumur Erica Morningstar Julia Wilkinson | DSQ |