| Event: | Women's 4 × 100 metre freestyle relay |
| Games: | 2006 |
| Venue: | Melbourne Sports and Aquatic Centre |
| Competitors: | 24 |
| Nations: | 6 |
| Win Value: | 3:36.49 GR |
| Gold: | Jodie Henry Alice Mills Shayne Reese |
| Goldcga: | AUS |
| Silver: | Rosalind Brett Amy Smith Fran Halsall |
| Silvercga: | ENG |
| Bronze: | Victoria Poon Geneviève Saumur Sophie Simard |
| Bronzecga: | CAN |
| Prev: | 2002 |
| Next: | 2010 |
The women's 4 × 100 metre freestyle relay event at the 2006 Commonwealth Games as part of the swimming programme took place on 20 March at the Melbourne Sports and Aquatic Centre in Melbourne, Australia.
Prior to this competition, the existing world and Commonwealth Games records were as follows.
The following records were established during the competition:
| Rank | Lane | Nation | Swimmers | Time | Notes | |
|---|---|---|---|---|---|---|
| 4 | (53.74) Jodie Henry (53.30) Alice Mills (54.42) Shayne Reese (55.03) | 3:36.49 | GR | |||
| 3 | (55.24) Rosalind Brett (55.22) Amy Smith (57.22) Fran Halsall (55.01) | 3:42.69 | ||||
| 5 | (55.63) Victoria Poon (56.24) Geneviève Saumur (54.85) Sophie Simard (56.12) | 3:42.84 | ||||
| 4 | 2 | (56.02) Alison Fitch (55.85) Helen Norfolk (56.17) Hannah McLean (55.45) | 3:43.49 | |||
| 5 | 6 | (57.39) Lauren Roets (55.07) Marielle Rogers (57.65) Kirsten van Heerden (57.88) | 3:47.99 | |||
| 6 | 7 | (59.38) Joscelin Yeo (56.45) Shu Yong Ho (59.18) Chui Bin Ong (59.14) | 3:54.15 |