| Event: | Men's 4 × 100 metre medley relay |
| Games: | 2006 |
| Venue: | Melbourne Sports and Aquatic Centre |
| Dates: | 21 March 2006 |
| Competitors: | 47 |
| Nations: | 9 |
| Win Value: | 3:34.37 |
| Goldcga: | AUS |
| Silvercga: | ENG |
| Bronzecga: | SCO |
| Prev: | 2002 |
| Next: | 2010 |
The men's 4 × 100 metre medley relay event at the 2006 Commonwealth Games took place on 21 March at the Melbourne Sports and Aquatic Centre, Australia.
The Australian team of Matthew Welsh, Brenton Rickard, Michael Klim and Eamon Sullivan won gold in Commonwealth Games record time, ahead of England's Liam Tancock, Christopher Cook, Matthew Bowe and Ross Davenport. The Scottish team of Gregor Tait, Kristopher Gilchrist, Todd Cooper and Craig Houston finished third.
Prior to this competition, the existing world and game records were as follows.
| World Record | 3:30.68 | Aaron Peirsol (53.45) Brendan Hansen (59.37) Ian Crocker (50.28) Jason Lezak (47.58) | USA | Athens, Greece | 21 August 2004 | |
| Games Record | 3:36.05 | Matt Welsh Jim Piper Geoff Huegill Ian Thorpe | AUS | Manchester, England | 4 August 2002 |
The Commonwealth Games record was broken by Australia in the final.
| Rank | Heat | Lane | Nation | Swimmers | Time | Notes | |
|---|---|---|---|---|---|---|---|
| 1 | 2 | 5 | Andrew Lauterstein (55.65) Christian Sprenger (1:02.76) Adam Pine (53.10) Kenrick Monk (49.96) | 3:41.47 | Q | ||
| 2 | 1 | 5 | Brian Johns (57.35) Scott Dickens (1:02.57) Thomas Kindler (55.31) Yannick Lupien (49.72) | 3:44.95 | Q | ||
| 3 | 1 | 3 | Scott Talbot (58.69) Glenn Snyders (1:03.41) Corney Swanepoel (52.79) Cameron Gibson (51.33) | 3:46.22 | Q | ||
| 4 | 1 | 4 | Liam Tancock (57.76) Chris Cook (1:02.28) Matthew Bowe (55.21) Ross Davenport (52.02) | 3:47.27 | Q | ||
| 5 | 2 | 3 | Gregor Tait (58.40) Christopher Jones (1:03.29) Todd Cooper (53.88) Craig Houston (52.18) | 3:47.75 | Q | ||
| 6 | 2 | 4 | Garth Tune (58.08) Thabang Moeketsane (1:03.47) George du Rand (54.41) Karl Thaning (51.98) | 3:47.94 | Q | ||
| 7 | 2 | 6 | Lee Yu Tan (59.04) Jin Wen Tan (1:08.36) Shirong Su (57.64) Zhirong Tay (52.22) | 3:57.26 | Q | ||
| 8 | 1 | 6 | Liam du Feu (1:03.04) Daniel Hawksworth (1:09.31) Simon le Couilliard (55.98) Alexis Militis (53.20) | 4:01.53 | Q | ||
| 9 | 2 | 2 | Thomas Hollingsworth (1:00.16) Jeremy Osborne (1:13.16) Ian Powell (55.23) Ian Hubert (54.08) | 4:02.63 |
| Rank | Lane | Nation | Swimmers | Time | Time behind | Notes | |
|---|---|---|---|---|---|---|---|
| 4 | Matt Welsh (54.84) Brenton Rickard (59.51) Michael Klim (51.87) Eamon Sullivan (48.15) | 3:34.37 | GR | ||||
| 6 | Liam Tancock (54.42) Chris Cook (1:00.29) Matthew Bowe (52.53) Ross Davenport (49.16) | 3:36.40 | 2.03 | ||||
| 2 | Gregor Tait (55.15) Kristopher Gilchrist (1:01.83) Todd Cooper (52.85) Craig Houston (49.92) | 3:39.75 | 5.38 | ||||
| 4 | 5 | Matthew Rose (56.29) Scott Dickens (1:01.32) Thomas Kindler (53.82) Brent Hayden (48.44) | 3:39.87 | 5.50 | |||
| 5 | 3 | Scott Talbot (55.77) Glenn Snyders (1:02.88) Moss Burmester (52.22) Cameron Gibson (49.88) | 3:40.75 | 6.38 | |||
| 6 | 7 | Gerhard Zandberg (55.81) Roland Schoeman (1:03.24) Ryk Neethling (52.97) Karl Thaning (49.76) | 3:41.78 | 7.41 | |||
| 7 | 1 | Lee Yu Tan (59.20) Jin Wen Tan (1:07.43) Shirong Su (57.51) Zhirong Tay (51.94) | 3:56.08 | 21.71 | |||
| 8 | 8 | Liam du Feu (1:03.20) Daniel Hawksworth (1:08.85) Simon le Couilliard (56.03) Alexis Militis (52.84) | 4:00.92 | 26.55 |