Surufatinib Explained

Width:	250
Tradename:	Sulanda
Atc Prefix:	L01
Atc Suffix:	EX24
Legal Status:	Rx-only
Synonyms:	Sulfatinib; HMPL-012
Cas Number:	1308672-74-3
Pubchem:	52920501
Chemspiderid:	57583328
Unii:	B2K5L1L8S9
Chembl:	4297190
Drugbank:	DB15106
Iuphar Ligand:	9769
Iupac Name:	N-[2-(Dimethylamino)ethyl]-1-[3-[[4-[(2-methyl-1''H''-indol-5-yl)oxy]pyrimidin-2-yl]amino]phenyl]methanesulfonamide
C:	24
H:	28
N:	6
O:	3
S:	1
Stdinchi:	1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2,1-3H3,(H,25,28,29)
Stdinchikey:	TTZSNFLLYPYKIL-UHFFFAOYSA-N
Smiles:	CC1=CC2=C(N1)C=CC(=C2)OC3=NC(=NC=C3)NC4=CC=CC(=C4)CS(=O)(=O)NCCN(C)C

Surufatinib (trade name Sulanda) is pharmaceutical drug for the treatment of cancer. In China, it is approved for late-stage, well-differentiated, extrapancreatic neuroendocrine tumors.^[1]

It is also under investigation for the treatment of other types of solid tumors.^[2] ^[3]

Surufatinib targets fibroblast growth factor receptor 1 (FGFR1).^[4]

Notes and References

Syed YY . Surufatinib: First Approval . Drugs . 81 . 6 . 727–732 . April 2021 . 33788183 . 10.1007/s40265-021-01489-y .
Liao S, Li J, Gao S, Han Y, Han X, Wu Y, Bi J, Xu M, Bi W . Sulfatinib, a novel multi-targeted tyrosine kinase inhibitor of FGFR1, CSF1R, and VEGFR1-3, suppresses osteosarcoma proliferation and invasion via dual role in tumor cells and tumor microenvironment . Frontiers in Oncology . 13 . 1158857 . 2023 . 37361567 . 10286821 . 10.3389/fonc.2023.1158857 . free .
10.1200/jco.2014.32.15_suppl.2615 . First-in-human (FIH) phase I study of a selective VEGFR/FGFR dual inhibitor sulfatinib with milled formulation in patients with advanced solid tumors . 2014 . Xu JM, Wang Y, Chen YL, Jia R, Shen L, Wang J, Sai Y, Qi C, Mu H . Journal of Clinical Oncology . 32 . 15_suppl . 2615 .
Lin Q, Dai S, Qu L, Lin H, Guo M, Wei H, Chen Y, Chen X . Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R . Communications Chemistry . 7 . 1 . 3 . January 2024 . 38172256 . 10764862 . 10.1038/s42004-023-01084-0 .