| Suresh H. Moolgavkar | |
| Birth Date: | 1943 1, df=yes |
| Birth Place: | Bombay, India |
| Fields: | Epidemiology, Mathematics |
| Workplaces: | University of Washington, Fred Hutchinson Cancer Research Center |
| Alma Mater: | Johns Hopkins University |
| Known For: | Two-stage Clonal Expansion (TSCE) Model of Carcinogenesis |
Suresh H. Moolgavkar (born 3 January 1943) is an Indian mathematician and epidemiologist who was at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle. He is a Senior Fellow and Research Scientist at Exponent, a consulting firm.[1] Among his many scientific contributions is the development of the two-stage clonal expansion (TSCE) model of carcinogenesis, also known as the Moolgavkar-Venzon-Knudson (MVK) model, a stochastic cell-level description of carcinogenesis based on Alfred G. Knudson’s two-hit hypothesis.[2] In its original development the TSCE model[3] represents tumor initiation as the first hit, followed by cell proliferation (clonal expansion) and malignant transformation as the second hit. It has been interpreted as describing the initiation-promotion-progression sequence observed in chemical carcinogenesis and has been applied widely for the analysis of both experimental and epidemiological data for purposes of quantitative risk assessment.