Superagonist Explained

In the field of pharmacology, a superagonist is a type of agonist that is capable of producing a maximal response greater than the endogenous agonist for the target receptor, and thus has an efficacy of more than 100%.^{[1] [2]} For example, goserelin is a superagonist of the gonadotropin-releasing hormone receptor.

See also

• Agonist

Notes and References

1. Carlier PR, Chow ES, Barlow RL, Bloomquist JR . Discovery of non-zwitterionic GABA_A receptor full agonists and a superagonist . Bioorg. Med. Chem. Lett. . 12 . 15 . 1985–8 . August 2002 . 12113824 . 10.1016/S0960-894X(02)00299-8.
2. Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE . Heterozygous α2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists . Proc. Natl. Acad. Sci. U.S.A. . 99 . 19 . 12471–6 . September 2002 . 12205290 . 129469 . 10.1073/pnas.122368499 . 2002PNAS...9912471T . free .