Suosan Explained

Suosan is calorie-free artificial sweetener derived from β-alanine, discovered in 1948 by Petersen et Muller.^[1]

Suosan is a sodium salt of p-Nitrophenylcarbamidopropionic acid and is 700 times sweeter than sucrose (table sugar)^[2] with a bitter aftertaste.^[3] It was never commercialized due to its low solubility in water, particularly under acidic pH (which limited its use, particularly in soft drinks)^{[4] [5]} and concerns that it might form the toxic compound 4-nitroaniline.

See also

• Aspartame

Notes and References

1. Petersen S. Muller E. Über eine neue Gruppe von Süsstoffen (On a new group of sweet substances). Chemische Berichte. 1948. 31–38. 81 . 10.1002/cber.19480810105 .
2. Santhosh . C. . Mishra . P. C. . 10.1002/qua.560510510 . Electrostatic potential and electric field mapping of some sweeteners of the suosan series: A search for the structure-activity relationship . International Journal of Quantum Chemistry . 51 . 5 . 335 . 1994 .
3. Book: AD Kinghorn & CM Compadre . Alternative Sweeteners . Third . Marcel Dekker . New York . 2001 . 0-8247-0437-1 . Less common high-potency sweeteners . 208–234.
4. Muller. George W. Culberson. J. Chris. Roy. Glenn. Ziegler. Jeanette. Walters. D. Eric. Kellogg. Michael S.. Schiffman. Susan S.. Warwick. Zoe S. Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1. J. Med. Chem.. May 1992. 35. 10. 1747–1751. 10.1021/jm00088a008. 1588556.
5. Web site: Nofre. Claude. Tinti. Jean M. Chatzopoulos. Farroudja O. Pyridinyl compounds of N-carbamoyl-N-thiocarbamoyl- or N-amidino-glycine or beta-alanine useful as sweetening agents. US Patent 4997667 A. 14 September 2014. Mar 5, 1991.